Literature DB >> 2898112

An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions.

T Nagatsu1, M Yoshida.   

Abstract

An endogenous substance of the human brain, tetrahydroisoquinoline (TIQ), that had been increased in the parkinsonian brain, produced parkinsonism in marmosets after daily injection of TIQ (50 mg/kg per day, s.c. for 11 days). Tyrosine hydroxylase activity, total biopterin and dopamine concentrations were also decreased in TIQ-treated marmosets. The results suggest that TIQ is one of the candidates of neurotoxins to produce parkinsonism.

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Year:  1988        PMID： 2898112     DOI： 10.1016/0304-3940(88)90166-8

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  15 in total

Review 1.  Mitochondrial dysfunction in neurodegeneration.

Authors:  J M Cooper; A H Schapira
Journal:  J Bioenerg Biomembr       Date:  1997-04       Impact factor: 2.945

Review 2.  A guide to neurotoxic animal models of Parkinson's disease.

Authors:  Kim Tieu
Journal:  Cold Spring Harb Perspect Med       Date:  2011-09       Impact factor: 6.915

3.  Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells.

Authors:  T Takahashi; W Maruyama; Y Deng; P Dostert; D Nakahara; T Niwa; S Ohta; M Naoi
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

Review 4.  Does mitochondrial DNA play a role in Parkinson's disease? A review of cybrid and other supportive evidence.

Authors:  Russell H Swerdlow
Journal:  Antioxid Redox Signal       Date:  2011-05-25       Impact factor: 8.401

5.  Neurotoxicity due to o-quinones: neuromelanin formation and possible mechanisms for o-quinone detoxification.

Authors:  F Solano; V J Hearing; J C García-Borrón
Journal:  Neurotox Res       Date:  2000-02       Impact factor: 3.911

6.  1-Benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous parkinsonism-inducing toxin, strongly potentiates MAO-dependent dopamine oxidation and impairs dopamine release: ex vivo and in vivo neurochemical studies.

Authors:  Agnieszka Wasik; Irena Romańska; Lucyna Antkiewicz-Michaluk
Journal:  Neurotox Res       Date:  2009-02-10       Impact factor: 3.911

7.  Inhibition of type A and B monoamine oxidase by 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines and their N-methylated derivatives.

Authors:  M Minami; W Maruyama; P Dostert; T Nagatsu; M Naoi
Journal:  J Neural Transm Gen Sect       Date:  1993

8.  Naturally-occurring isoquinolines perturb monamine metabolism in the brain: studied by in vivo microdialysis.

Authors:  W Maruyama; D Nakahara; P Dostert; A Takahashi; M Naoi
Journal:  J Neural Transm Gen Sect       Date:  1993

9.  Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system.

Authors:  T Takahashi; Y Deng; W Maruyama; P Dostert; M Kawai; M Naoi
Journal:  J Neural Transm Gen Sect       Date:  1994

10.  Inhibition of mitochondrial respiration by 1,2,3,4-tetrahydroisoquinoline-like endogenous alkaloids in mouse brain.

Authors:  K Suzuki; Y Mizuno; M Yoshida
Journal:  Neurochem Res       Date:  1990-07       Impact factor: 3.996
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