Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis.

Literature DB >> 28980868

Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis.

Weiguo Zhang¹, Gary H Karpen¹, Qing Zhang².

Abstract

Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.

Entities: Chemical Disease Gene

Keywords: CENP-A; Cyclin E1; FBW7; centromere; chromosome instability; tumorigenesis

Mesh：

Substances：

Year: 2017 PMID： 28980868 PMCID： PMC5788445 DOI： 10.1080/15384101.2017.1387698

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

35 in total

1. Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice.

Authors: E V Howman; K J Fowler; A J Newson; S Redward; A C MacDonald; P Kalitsis; K H Choo
Journal: Proc Natl Acad Sci U S A Date: 2000-02-01 Impact factor: 11.205

2. Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone.

Authors: Harmit S Malik; Danielle Vermaak; Steven Henikoff
Journal: Proc Natl Acad Sci U S A Date: 2002-01-22 Impact factor: 11.205

3. A novel role of the N terminus of budding yeast histone H3 variant Cse4 in ubiquitin-mediated proteolysis.

Authors: Wei Chun Au; Anthony R Dawson; David W Rawson; Sara B Taylor; Richard E Baker; Munira A Basrai
Journal: Genetics Date: 2013-03-22 Impact factor: 4.562

4. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP.

Authors: Hao Hu; Yang Liu; Mingzhu Wang; Junnan Fang; Hongda Huang; Na Yang; Yanbo Li; Jianyu Wang; Xuebiao Yao; Yunyu Shi; Guohong Li; Rui-Ming Xu
Journal: Genes Dev Date: 2011-04-08 Impact factor: 11.361

5. The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer.

Authors: Zhi Hu; Ge Huang; Anguraj Sadanandam; Shenda Gu; Marc E Lenburg; Melody Pai; Nora Bayani; Eleanor A Blakely; Joe W Gray; Jian-Hua Mao
Journal: Breast Cancer Res Date: 2010-03-08 Impact factor: 6.466

6. A two-step mechanism for epigenetic specification of centromere identity and function.

Authors: Daniele Fachinetti; H Diego Folco; Yael Nechemia-Arbely; Luis P Valente; Kristen Nguyen; Alex J Wong; Quan Zhu; Andrew J Holland; Arshad Desai; Lars E T Jansen; Don W Cleveland
Journal: Nat Cell Biol Date: 2013-07-21 Impact factor: 28.824

7. Mislocalization of the Drosophila centromere-specific histone CID promotes formation of functional ectopic kinetochores.

Authors: Patrick Heun; Sylvia Erhardt; Michael D Blower; Samara Weiss; Andrew D Skora; Gary H Karpen
Journal: Dev Cell Date: 2006-03 Impact factor: 12.270

8. Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells.

Authors: Prashant K Mishra; Wei-Chun Au; John S Choy; P Henning Kuich; Richard E Baker; Daniel R Foltz; Munira A Basrai
Journal: PLoS Genet Date: 2011-09-29 Impact factor: 5.917

9. Meiosis-specific loading of the centromere-specific histone CENH3 in Arabidopsis thaliana.

Authors: Maruthachalam Ravi; Fukashi Shibata; Joseph S Ramahi; Kiyotaka Nagaki; Changbin Chen; Minoru Murata; Simon W L Chan
Journal: PLoS Genet Date: 2011-06-09 Impact factor: 5.917

10. Functional analysis of kinetochore assembly in Caenorhabditis elegans.

Authors: K Oegema; A Desai; S Rybina; M Kirkham; A A Hyman
Journal: J Cell Biol Date: 2001-06-11 Impact factor: 10.539

4 in total

1. A comprehensive investigation on pan-cancer impacts of constitutive centromere associated network gene family by integrating multi-omics data: A CONSORT-compliant article.

Authors: Huimei Su; Yuchun Fan; Zhuan Wang; Lihe Jiang
Journal: Medicine (Baltimore) Date: 2022-02-18 Impact factor: 1.817