Literature DB >> 2898033

Interaction of SM-3997 with serotonin receptors in rat brain.

H Shimizu1, N Karai, A Hirose, T Tatsuno, H Tanaka, Y Kumasaka, M Nakamura.   

Abstract

The propensity of SM-3997 to displace 3H-ligands was tested in vitro in a number of receptor-binding assays. SM-3997 possessed a high affinity towards 5-HT1A receptors, low affinity towards dopamine (D2) and 5-HT2 receptors, and no affinity towards benzodiazepine (BZ), GABA, 5-HT1B and adrenergic receptors. Moreover, SM-3997 facilitated neither 3H-flunitrazepam binding nor 3H-muscimol binding. These results suggest that the action of SM-3997 may be mediated via central 5-HT1A receptors but not the BZ-GABA receptor complex.

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Year:  1988        PMID： 2898033     DOI： 10.1254/jjp.46.311

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN： 0021-5198


  6 in total

1.  Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes.

Authors:  Kiyohi Natsui; Yoshiko Mizuno; Naoko Tani; Masashi Yabuki; Setsuko Komuro
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2007 Oct-Dec       Impact factor: 2.441

2.  Efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea and anxiety.

Authors:  Ling Lan; Yu-Long Chen; Hao Zhang; Bai-Ling Jia; Yan-Jun Chu; Jin Wang; Shi-Xiao Tang; Guo-Dong Xia
Journal:  World J Gastroenterol       Date:  2014-08-28       Impact factor: 5.742

3.  Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes.

Authors:  Kiyohi Natsui; Yoshiko Mizuno; Naoko Tani; Masashi Yabuki; Setsuko Komuro
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2007 Jul-Sep       Impact factor: 2.441

4.  Effects of selective 5-HT1A agonist tandospirone on the rate and rhythmicity of binocular rivalry.

Authors:  Masanori Nagamine; Aihide Yoshino; Masaki Miyazaki; Yoshitomo Takahashi; Soichiro Nomura
Journal:  Psychopharmacology (Berl)       Date:  2008-04-12       Impact factor: 4.530

5.  Serotonin (5-HT)1A receptor agonism and 5-HT7 receptor antagonism ameliorate the subchronic phencyclidine-induced deficit in executive functioning in mice.

Authors:  Lakshmi Rajagopal; Bill W Massey; Eric Michael; Herbert Y Meltzer
Journal:  Psychopharmacology (Berl)       Date:  2015-11-12       Impact factor: 4.530

6.  Inhibition by 8-hydroxy-2-(di-n-propylamino) tetralin and SM-3997, a novel anxiolytic drug, of the hippocampal rhythmical slow activity mediated by 5-hydroxytryptamine1A receptors.

Authors:  A Hirose; R Tsuji; H Shimizu; T Tatsuno; H Tanaka; Y Kumasaka; M Nakamura
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000
  6 in total

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