BACKGROUND: Laparoscopic stripping is the gold-standard treatment for ovarian endometriosis. The choice of hemostasis method might affect ovarian reserve. OBJECTIVES: To determine whether bipolar electrocoagulation is more detrimental to ovarian reserve than non-thermal hemostasis methods. SEARCH STRATEGY: Entry terms associated with the MeSH terms "endometrioma," "laparoscopy," and "ovarian reserve" were used to search databases for articles published up to April 3, 2017, in English, Spanish, Portuguese, French, and Italian. SELECTION CRITERIA: Randomized controlled trials comparing the 3-month postoperative serum anti-Müllerian hormone (AMH) level in premenopausal women undergoing laparoscopic stripping with bipolar hemostasis or non-thermal hemostasis methods were selected. DATA COLLECTION AND ANALYSIS: Data were extracted by two independent reviewers and a meta-analysis was performed. MAIN RESULTS: Three studies met the inclusion criteria; overall, 105 patients underwent surgery with bipolar electrocoagulation and 105 patients underwent surgery with an alternative hemostasis method. The AMH level 3 months after surgery was decreased in the bipolar electrocoagulation group (mean difference -0.79 ng/mL, 95% confidence interval -1.19 to -0.39). CONCLUSIONS: Bipolar electrocoagulation negatively impacts ovarian reserve and should be avoided, especially for patients with reproductive goals.
BACKGROUND: Laparoscopic stripping is the gold-standard treatment for ovarian endometriosis. The choice of hemostasis method might affect ovarian reserve. OBJECTIVES: To determine whether bipolar electrocoagulation is more detrimental to ovarian reserve than non-thermal hemostasis methods. SEARCH STRATEGY: Entry terms associated with the MeSH terms "endometrioma," "laparoscopy," and "ovarian reserve" were used to search databases for articles published up to April 3, 2017, in English, Spanish, Portuguese, French, and Italian. SELECTION CRITERIA: Randomized controlled trials comparing the 3-month postoperative serum anti-Müllerian hormone (AMH) level in premenopausal women undergoing laparoscopic stripping with bipolar hemostasis or non-thermal hemostasis methods were selected. DATA COLLECTION AND ANALYSIS: Data were extracted by two independent reviewers and a meta-analysis was performed. MAIN RESULTS: Three studies met the inclusion criteria; overall, 105 patients underwent surgery with bipolar electrocoagulation and 105 patients underwent surgery with an alternative hemostasis method. The AMH level 3 months after surgery was decreased in the bipolar electrocoagulation group (mean difference -0.79 ng/mL, 95% confidence interval -1.19 to -0.39). CONCLUSIONS: Bipolar electrocoagulation negatively impacts ovarian reserve and should be avoided, especially for patients with reproductive goals.
Authors: Ana Sofia Pais; Clara Flagothier; Linda Tebache; Teresa Almeida Santos; Michelle Nisolle Journal: J Clin Med Date: 2021-01-22 Impact factor: 4.241