Literature DB >> 2898024

Effects of five alpha-blockers on the hypogastric nerve stimulation of the canine lower urinary tract.

M Poirier1, J P Riffaud, J Y Lacolle, C Dupont.   

Abstract

Electrical stimulation of the hypogastric nerve increased both urethral and bladder pressures of anaesthetized male dogs, without affecting cardiovascular parameters. Intravenous injections of prazosin, phentolamine, thymoxamine, phenoxybenzamine and yohimbine inhibited the urethral pressure increase in a dose-dependent manner, but the increase in bladder pressure was not modified by these alpha-blockers.

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Year:  1988        PMID: 2898024     DOI: 10.1016/s0022-5347(17)41519-9

Source DB:  PubMed          Journal:  J Urol        ISSN: 0022-5347            Impact factor:   7.450


  3 in total

1.  Mechanisms of reflex bladder activation by pudendal afferents.

Authors:  John P Woock; Paul B Yoo; Warren M Grill
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-11-10       Impact factor: 3.619

2.  Urethral pressure profile and hemodynamic effects of phenoxybenzamine and prazosin in non-sedated male beagle dogs.

Authors:  Julie R Fischer; India F Lane; Alastair E Cribb
Journal:  Can J Vet Res       Date:  2003-01       Impact factor: 1.310

3.  Pharmacokinetics of a prodrug thymoxamine: dose-dependence of the metabolite ratio in healthy subjects.

Authors:  C Marquer; J H Trouvin; J Y Lacolle; C Dupont; C Jacquot
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1991 Jul-Sep       Impact factor: 2.441

  3 in total

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