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Literature DB >> 28979809

MiRNA-107 enhances chemosensitivity to paclitaxel by targeting antiapoptotic factor Bcl-w in non small cell lung cancer.

Chaojing Lu¹, Zhibing Xie², Qingzhen Peng².

Abstract

The aim of this study is to elucidate whether and how miR-107 participates in the modulation of paclitaxel sensitivity in non small cell lung cancer (NSCLC). By qRT-PCR, we found that miR-107 is significantly down-regulated in paclitaxel-resistant A549/Taxol cells compared with corresponding paclitaxel-sensitive counterparts. Overexpression of miR-107 suppresses paclitaxel resistance of A549/Taxol cells through directly inhibiting Bcl-w. Overexpression of miR-107 promotes apoptosis and inhibits proliferation and mobility of A549/Taxol cells under treatment with paclitaxel in vitro. Moreover, miR-107 inhibits in vivo paclitaxel resistance in xenograft model. MiR-107/Bcl-w axis regulates paclitaxel chemoresistance through PI3K-Akt pathway. Our results suggest that up-regulation of miR-107 resensitizes paclitaxel-resistant NSCLC cells by targeting Bcl-w, which reveals a potential mechanism of miR-107 in reversing drug resistance.

Entities: Chemical Disease Gene

Keywords: Bcl-w; Non small cell lung cancer; PI3K-Akt pathway; chemoresistance; microRNA-107

Year: 2017 PMID： 28979809 PMCID： PMC5622221

Source DB: PubMed Journal: Am J Cancer Res ISSN： 2156-6976 Impact factor: 6.166

42 in total

1. High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma.

Authors: Sara Correia Marques; Benyamin Ranjbar; Maria Bach Laursen; Steffen Falgreen; Anders Ellern Bilgrau; Julie Støve Bødker; Laura Krogh Jørgensen; Maria Nascimento Primo; Alexander Schmitz; Marianne Schmidt Ettrup; Hans Erik Johnsen; Martin Bøgsted; Jacob Giehm Mikkelsen; Karen Dybkær
Journal: Exp Hematol Date: 2016-02-17 Impact factor: 3.084

2. Non-small cell lung cancer, version 2.2013.

Authors: David S Ettinger; Wallace Akerley; Hossein Borghaei; Andrew C Chang; Richard T Cheney; Lucian R Chirieac; Thomas A D'Amico; Todd L Demmy; Ramaswamy Govindan; Frederic W Grannis; Stefan C Grant; Leora Horn; Thierry M Jahan; Ritsuko Komaki; Feng-Ming Spring Kong; Mark G Kris; Lee M Krug; Rudy P Lackner; Inga T Lennes; Billy W Loo; Renato Martins; Gregory A Otterson; Jyoti D Patel; Mary C Pinder-Schenck; Katherine M Pisters; Karen Reckamp; Gregory J Riely; Eric Rohren; Theresa A Shapiro; Scott J Swanson; Kurt Tauer; Douglas E Wood; Stephen C Yang; Kristina Gregory; Miranda Hughes
Journal: J Natl Compr Canc Netw Date: 2013-06-01 Impact factor: 11.908

Review 3. MicroRNAs: promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential.

Authors: Christiane Matuszcak; Joerg Haier; Richard Hummel; Kirsten Lindner
Journal: World J Gastroenterol Date: 2014-10-14 Impact factor: 5.742

4. MCL-1 is the key target of adjuvant chemotherapy to reverse the cisplatin-resistance in NSCLC.

Authors: Jun Ma; Zhenxian Zhao; Kaiming Wu; Zhe Xu; Kuanzhi Liu
Journal: Gene Date: 2016-04-29 Impact factor: 3.688

5. A microRNA-related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients.

Authors: Zhanjun Guo; Hongjing Wang; Yantao Li; Bin Li; Cuiqiao Li; Cuimin Ding
Journal: Biomed Rep Date: 2013-03-29

6. Paclitaxel (Taxol®): A new natural product with major anticancer activity.

Authors: M D De Furia
Journal: Phytomedicine Date: 1997-09 Impact factor: 5.340

7. miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers.

Authors: Liqin Du; Maria C Subauste; Christopher DeSevo; Zhenze Zhao; Michael Baker; Robert Borkowski; Jeoffrey J Schageman; Rachel Greer; Chin-Rang Yang; Milind Suraokar; Ignacio I Wistuba; Adi F Gazdar; John D Minna; Alexander Pertsemlidis
Journal: PLoS One Date: 2012-06-18 Impact factor: 3.240

Review 8. Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases.

Authors: Masaru Katoh
Journal: Front Cell Dev Biol Date: 2014-10-16

9. MicroRNA-7 sensitizes non-small cell lung cancer cells to paclitaxel.

Authors: Ronghua Liu; Xiaoming Liu; Yijie Zheng; Jie Gu; Shudao Xiong; Pei Jiang; Xuechao Jiang; Enyu Huang; Yixian Yang; DI Ge; Yiwei Chu
Journal: Oncol Lett Date: 2014-09-04 Impact factor: 2.967

10. MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1.

Authors: Lin Wang; Cheng-fei Jiang; Dong-mei Li; Xin Ge; Zhu-mei Shi; Chong-yong Li; Xue Liu; Yu Yin; Linlin Zhen; Ling-Zhi Liu; Bing-Hua Jiang
Journal: Oncotarget Date: 2016-01-19

23 in total

1. MicroRNA-6852 suppresses cell proliferation and invasion via targeting forkhead box J1 in gastric cancer.

Authors: Hui Yu; Jing Zhang; Qu Wen; Yi Dai; Wanli Zhang; Fen Li; Juan Li
Journal: Exp Ther Med Date: 2018-08-02 Impact factor: 2.447

2. BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines.

Authors: Sarah T Diepstraten; Catherine Chang; Lin Tai; Jia-Nan Gong; Ping Lan; Alexander C Dowell; Graham S Taylor; Andreas Strasser; Gemma L Kelly
Journal: Blood Adv Date: 2020-01-28

3. MicroRNA-1294 inhibits the proliferation and enhances the chemosensitivity of glioma to temozolomide via the direct targeting of TPX2.

Authors: Hua Chen; Liang Liu; Xiaojian Li; Yan Shi; Ning Liu
Journal: Am J Cancer Res Date: 2018-02-01 Impact factor: 6.166

MiRNA-107 enhances chemosensitivity to paclitaxel by targeting antiapoptotic factor Bcl-w in non small cell lung cancer.

1. High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma.

2. Non-small cell lung cancer, version 2.2013.

Review 3. MicroRNAs: promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential.

4. MCL-1 is the key target of adjuvant chemotherapy to reverse the cisplatin-resistance in NSCLC.

5. A microRNA-related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients.

6. Paclitaxel (Taxol®): A new natural product with major anticancer activity.

7. miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers.

Review 8. Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases.

9. MicroRNA-7 sensitizes non-small cell lung cancer cells to paclitaxel.

10. MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1.

1. MicroRNA-6852 suppresses cell proliferation and invasion via targeting forkhead box J1 in gastric cancer.

2. BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines.

3. MicroRNA-1294 inhibits the proliferation and enhances the chemosensitivity of glioma to temozolomide via the direct targeting of TPX2.

4. MicroRNA-30e inhibits proliferation and invasion of non-small cell lung cancer via targeting SOX9.

Review 5. Mechanisms of resistance to chemotherapy in non-small cell lung cancer.

Review 6. Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members.

7. miR-210-3p Promotes Lung Cancer Development and Progression by Modulating USF1 and PCGF3.

Review 8. A meta-analytic review of the association between two common SNPs in miRNAs and lung cancer susceptibility.

Review 9. Perturbing mitosis for anti-cancer therapy: is cell death the only answer?

10. Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells.