MicroRNAs: new players in cataract.

Cataract is the most common cause of blindness worldwide. Multiple factors such as aging, eye injury, diabetes mellitus, ultraviolet exposure, drug use and other ocular diseases are etiologically linked to cataractogenesis. Due to a rapid increase in aging population, age-related cataract has become the leading cause of blindness. Therefore, it is urgent to understand the molecular mechanism underlying cataractogenesis. MicroRNAs (miRNAs) are a group of endogenous, small noncoding RNAs that regulate gene expression at the post-translational level through binding with the 3'-untranslated regions of target mRNAs. Studies have shown that miRNAs play important roles in multiple cellular functions, including apoptosis, cell proliferation, senescence and stress response. Deregulated expression of miRNAs is also linked to the pathogenesis of many diseases, including ocular diseases. In our review, we focus on miRNAs that are involved in cataract development and discuss their potential applications as novel diagnostic markers and therapeutic targets.