| Literature DB >> 28979377 |
Andrew S Lane1,2, Bernard Champion1,2, Sam Orde2, Danijela Dravec1,2.
Abstract
Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D), which without treatment leads to death. Fulminant type 1 diabetes (FT1D) is a subtype characterised by a markedly rapid and almost complete destruction of pancreatic β-cells, with acute onset leading to severe metabolic derangement and commonly ICU admission. We present a case of an 18-year-old male presenting with FT1D with two rare complications of pneumomediastinum and stress-induced cardiomyopathy (SIC) with significant myocardial necrosis. We also discuss the aetiology of the pneumomediastinum; the latest thoughts on SIC: moving beyond the simple description of 'Takotsubo cardiomyopathy'; the role of troponins in critical illness; and genetic predisposition for DKA due to FT1D.Entities:
Keywords: Fulminant type 1 diabetes; Takotsubo cardiomyopathy; pneumomediastinum; stress induced cardiomyopathy; troponin
Year: 2014 PMID: 28979377 PMCID: PMC5593281 DOI: 10.1177/1751143714551249
Source DB: PubMed Journal: J Intensive Care Soc ISSN: 1751-1437