Literature DB >> 28978598

Unusual case of immune-related colitis.

Meltiady Issa1, Ioannis Milioglou2.   

Abstract

The cancer immunotherapy field has had many promising developments in recent years. Checkpoint inhibitors are good examples of that. This new class of medications comes with a new constellation of side effects that require early recognition and management. Here we present a patient with metastatic adenocarcinoma on pembrolizumab who was admitted to the hospital for colitis. This was found to be an immune-related adverse event from pembrolizumab. We discuss our work-up and approach to the diagnosis, then highlight important treatment pearls for internal medicine physicians who are increasingly taking care of such patients. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  immunological products and vaccines; malignant disease and immunosuppression; unwanted effects / adverse reactions

Mesh:

Substances:

Year:  2017        PMID: 28978598      PMCID: PMC5652473          DOI: 10.1136/bcr-2017-221319

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  10 in total

Review 1.  Immune checkpoint inhibitors in challenging populations.

Authors:  Douglas B Johnson; Ryan J Sullivan; Alexander M Menzies
Journal:  Cancer       Date:  2017-02-27       Impact factor: 6.860

Review 2.  Managing immune checkpoint-blocking antibody side effects.

Authors:  Michael A Postow
Journal:  Am Soc Clin Oncol Educ Book       Date:  2015

Review 3.  Immune Checkpoint Inhibitor Therapy: What Line of Therapy and How to Choose?

Authors:  Chethan Ramamurthy; James L Godwin; Hossein Borghaei
Journal:  Curr Treat Options Oncol       Date:  2017-06

Review 4.  Management of toxicities of immune checkpoint inhibitors.

Authors:  Lavinia Spain; Stefan Diem; James Larkin
Journal:  Cancer Treat Rev       Date:  2016-02-06       Impact factor: 12.111

5.  Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.

Authors:  James Larkin; Vanna Chiarion-Sileni; Rene Gonzalez; Jean Jacques Grob; C Lance Cowey; Christopher D Lao; Dirk Schadendorf; Reinhard Dummer; Michael Smylie; Piotr Rutkowski; Pier F Ferrucci; Andrew Hill; John Wagstaff; Matteo S Carlino; John B Haanen; Michele Maio; Ivan Marquez-Rodas; Grant A McArthur; Paolo A Ascierto; Georgina V Long; Margaret K Callahan; Michael A Postow; Kenneth Grossmann; Mario Sznol; Brigitte Dreno; Lars Bastholt; Arvin Yang; Linda M Rollin; Christine Horak; F Stephen Hodi; Jedd D Wolchok
Journal:  N Engl J Med       Date:  2015-05-31       Impact factor: 91.245

6.  Diagnostic Comparison of CT Scans and Colonoscopy for Immune-Related Colitis in Ipilimumab-Treated Advanced Melanoma Patients.

Authors:  Marlene Garcia-Neuer; Melina E Marmarelis; Sushrut R Jangi; Jason J Luke; Nageatte Ibrahim; Meredith Davis; Janice Weinberg; Hilary Donahue; Nancy Bailey; F Stephen Hodi; Elizabeth L Buchbinder; Patrick A Ott
Journal:  Cancer Immunol Res       Date:  2017-04       Impact factor: 11.151

7.  Immune Checkpoint Inhibitor-Induced Colitis: Diagnosis and Management.

Authors:  Caroline Prieux-Klotz; Marie Dior; Diane Damotte; Johann Dreanic; Bertrand Brieau; Catherine Brezault; Vered Abitbol; Stanislas Chaussade; Romain Coriat
Journal:  Target Oncol       Date:  2017-06       Impact factor: 4.493

Review 8.  Drug-induced gastrointestinal disorders.

Authors:  H L Philpott; S Nandurkar; J Lubel; P R Gibson
Journal:  Postgrad Med J       Date:  2014-07       Impact factor: 2.401

Review 9.  From targeting the tumor to targeting the immune system: Transversal challenges in oncology with the inhibition of the PD-1/PD-L1 axis.

Authors:  Melissa Bersanelli; Sebastiano Buti
Journal:  World J Clin Oncol       Date:  2017-02-10

Review 10.  Treatment of the Immune-Related Adverse Effects of Immune Checkpoint Inhibitors: A Review.

Authors:  Claire F Friedman; Tracy A Proverbs-Singh; Michael A Postow
Journal:  JAMA Oncol       Date:  2016-10-01       Impact factor: 31.777

  10 in total
  1 in total

1.  New drugs and new toxicities: pembrolizumab-induced myocarditis.

Authors:  Faisal Inayat; Muhammad Masab; Sorab Gupta; Waqas Ullah
Journal:  BMJ Case Rep       Date:  2018-01-23
  1 in total

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