Literature DB >> 2897857

Calmodulin antagonists of improved potency and specificity for use in the study of calmodulin biochemistry.

S MacNeil1, M Griffin, A M Cooke, N J Pettett, R A Dawson, R Owen, G M Blackburn.   

Abstract

Syntheses are described for a range of N-(omega-aminoalkyl)-5-iodo- and -5-cyanonaphthalene-1-sulphonamides. The selective activity of these compounds as inhibitors for calmodulin-dependent phosphodiesterase (EC 3.1.4.17) is compared with their activity for the calmodulin-independent but calcium-dependent enzymes protein kinase C and transglutaminase (EC 2.3.2.13). The results show a drastic improvement in the selectivity of effect for the 5-iodo-compounds compared with the widely-used drug, W7, N-(6-aminohexyl)-5-chloronaphthalene-1-sulphonamide.

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Year:  1988        PMID： 2897857     DOI： 10.1016/0006-2952(88)90434-0

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  8 in total

1.  Alignment of weakly interacting molecules to protein surfaces using simulations of chemical shift perturbations.

Authors:  M A McCoy; D F Wyss
Journal:  J Biomol NMR       Date:  2000-11       Impact factor: 2.835

2.  NMR and molecular dynamics studies of the interaction of melatonin with calmodulin.

Authors:  Adrián G Turjanski; Darío A Estrin; Ruth E Rosenstein; John E McCormick; Stephen R Martin; Annalisa Pastore; Rodolfo R Biekofsky; Vincenzo Martorana
Journal:  Protein Sci       Date:  2004-11       Impact factor: 6.725

3.  Direct stimulation of adenylyl cyclase 9 by the fungicide imidazole miconazole.

Authors:  James Simpson; Adrienn Pálvölgyi; Ferenc A Antoni
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2019-01-03       Impact factor: 3.000

4.  Calmodulin independence of human duodenal adenylate cyclase.

Authors:  J A Smith; M Griffin; S E Mireylees; R G Long
Journal:  Gut       Date:  1991-11       Impact factor: 23.059

5.  Investigation of the role of signal transduction in attachment of ocular melanoma cells to matrix proteins: inhibition of attachment by calmodulin antagonists including tamoxifen.

Authors:  S Mac Neil; M Wagner; I G Rennie
Journal:  Clin Exp Metastasis       Date:  1994-11       Impact factor: 5.150

6.  Calmodulin content and activity in normal and coeliac duodenum.

Authors:  J Amoah; C Williams; R G Long
Journal:  Gut       Date:  1992-03       Impact factor: 23.059

7.  Tamoxifen, 17beta-oestradiol and the calmodulin antagonist J8 inhibit human melanoma cell invasion through fibronectin.

Authors:  L O Dewhurst; J W Gee; I G Rennie; S MacNeil
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

8.  Suggested Involvement of PP1/PP2A Activity and De Novo Gene Expression in Anhydrobiotic Survival in a Tardigrade, Hypsibius dujardini, by Chemical Genetic Approach.

Authors:  Koyuki Kondo; Takeo Kubo; Takekazu Kunieda
Journal:  PLoS One       Date:  2015-12-21       Impact factor: 3.240
  8 in total

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