Literature DB >> 28978405

A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction.

Georges Mer1, Maria Victoria Botuyan2.   

Abstract

Tandem BRCT domains are phophoprotein binding modules. In this issue of Structure, Sun et al. (2017) show that a single BRCT domain in TopBP1 binds tightly and specifically to phosphorylated Bloom syndrome helicase (BLM). This work reveals a novel BRCT binding mode and suggests a similar mechanism for TopBP1 interaction with 53BP1.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28978405      PMCID： PMC5642270          DOI： 10.1016/j.str.2017.09.011

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  12 in total

1.  Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.

Authors:  Maria Victoria E Botuyan; Yves Nominé; Xiaochun Yu; Nenad Juranic; Slobodan Macura; Junjie Chen; Georges Mer
Journal:  Structure       Date:  2004-07       Impact factor: 5.006

Review 2.  Interactions between BRCT repeats and phosphoproteins: tangled up in two.

Authors:  J N Mark Glover; R Scott Williams; Megan S Lee
Journal:  Trends Biochem Sci       Date:  2004-11       Impact factor: 13.807

3.  Structural Insight into BLM Recognition by TopBP1.

Authors:  Luxin Sun; Yuhao Huang; Ross A Edwards; Sukmin Yang; Andrew N Blackford; Wojciech Niedzwiedz; J N Mark Glover
Journal:  Structure       Date:  2017-09-14       Impact factor: 5.006

4.  Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites.

Authors:  Chao Xu; Liming Wu; Gaofeng Cui; Maria Victoria Botuyan; Junjie Chen; Georges Mer
Journal:  J Mol Biol       Date:  2008-06-14       Impact factor: 5.469

5.  TopBP1 controls BLM protein level to maintain genome stability.

Authors:  Jiadong Wang; Junjie Chen; Zihua Gong
Journal:  Mol Cell       Date:  2013-11-14       Impact factor: 17.970

6.  BRCT repeats as phosphopeptide-binding modules involved in protein targeting.

Authors:  Isaac A Manke; Drew M Lowery; Anhco Nguyen; Michael B Yaffe
Journal:  Science       Date:  2003-10-24       Impact factor: 47.728

7.  Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control.

Authors:  Charles Chung Yun Leung; Luxin Sun; Zihua Gong; Michael Burkat; Ross Edwards; Mark Assmus; Junjie Chen; J N Mark Glover
Journal:  Structure       Date:  2013-07-25       Impact factor: 5.006

8.  Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1).

Authors:  Meng Qu; Mathieu Rappas; Christopher P Wardlaw; Valerie Garcia; Jing-Yi Ren; Matthew Day; Antony M Carr; Antony W Oliver; Li-Lin Du; Laurence H Pearl
Journal:  Mol Cell       Date:  2013-09-26       Impact factor: 17.970

9.  MDC1 collaborates with TopBP1 in DNA replication checkpoint control.

Authors:  Jiadong Wang; Zihua Gong; Junjie Chen
Journal:  J Cell Biol       Date:  2011-04-11       Impact factor: 10.539

10.  TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Authors:  Andrew N Blackford; Jadwiga Nieminuszczy; Rebekka A Schwab; Yaron Galanty; Stephen P Jackson; Wojciech Niedzwiedz
Journal:  Mol Cell       Date:  2015-03-19       Impact factor: 17.970
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  1 in total

1.  Phosphoproteomics reveals a distinctive Mec1/ATR signaling response upon DNA end hyper-resection.

Authors:  Ethan J Sanford; William J Comstock; Vitor M Faça; Stephanie C Vega; Robert Gnügge; Lorraine S Symington; Marcus B Smolka
Journal:  EMBO J       Date:  2021-03-25       Impact factor: 11.598
  1 in total

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