| Literature DB >> 28976773 |
Diana Jæger1,2, Chi P Ndi1, Christoph Crocoll3, Bradley S Simpson4, Bekzod Khakimov5, Ruth Marian Guzman-Genuino1,6,7, John D Hayball1,6,7, Xiaohui Xing8,9, Vincent Bulone8,9, Philip Weinstein10, Birger L Møller2, Susan J Semple1.
Abstract
The Australian plant Acacia ligulata has a number of traditional food and medicinal uses by Australian Aboriginal people, although no bioactive compounds have previously been isolated from this species. Bioassay-guided fractionation of an ethanolic extract of the mature pods of A. ligulata led to the isolation of the two new echinocystic acid triterpenoid saponins, ligulatasides A (1) and B (2), which differ in the fine structure of their glycan substituents. Their structures were elucidated on the basis of 1D and 2D NMR, GC-MS, LC-MS/MS, and saccharide linkage analysis. These are the first isolated compounds from A. ligulata and the first fully elucidated structures of triterpenoid saponins from Acacia sensu stricto having echinocystic acid reported as the aglycone. Compounds 1 and 2 were evaluated for cytotoxic activity against a human melanoma cancer cell line (SK-MEL28) and a diploid fibroblast cell line (HFF), but showed only weak activity.Entities:
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Year: 2017 PMID： 28976773 DOI： 10.1021/acs.jnatprod.7b00437
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050