Vivian K Kawai1, Rebecca T Levinson2, Abiodun Adefurin1,3, Daniel Kurnik1,4,5, Sarah P Collier6, Douglas Conway6, Charles Michael Stein1. 1. Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. 2. Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. 3. Department of Internal Medicine, Meharry Medical College, Nashville, TN 37208, USA. 4. Clinical Pharmacology Unit, Rambam Health Care Campus, Haifa, Israel. 5. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. 6. Vanderbilt Institute for Clinical & Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203, USA.
Abstract
AIM: Sympathetic activation suppresses insulin secretion via pancreatic ADRA2A. Because sympathetic activity and insulin demand increase during pregnancy, we tested the hypothesis that ADRA2A variants are associated with gestational diabetes (GDM). PATIENTS & METHODS: Among Caucasian pregnant women without pre-existing diabetes, we genotyped 458 who had GDM and 1537 without GDM for seven ADRA2A variants. RESULTS: rs1800038 (OR: 2.34; p = 0.020) and rs3750625 (OR: 1.56; p = 0.010) increased the risk of GDM, and rs11195418 decreased it (OR: 0.62; p = 0.025). The associations remained significant after adjustment for maternal age, maternal BMI, parity and a genetic risk score that included variants previously associated with Type 2 diabetes mellitus and GDM. CONCLUSION: ADRA2A genetic variation contributes independently to the risk of GDM in Caucasian women.
AIM: Sympathetic activation suppresses insulin secretion via pancreaticADRA2A. Because sympathetic activity and insulin demand increase during pregnancy, we tested the hypothesis that ADRA2A variants are associated with gestational diabetes (GDM). PATIENTS & METHODS: Among Caucasian pregnant women without pre-existing diabetes, we genotyped 458 who had GDM and 1537 without GDM for seven ADRA2A variants. RESULTS:rs1800038 (OR: 2.34; p = 0.020) and rs3750625 (OR: 1.56; p = 0.010) increased the risk of GDM, and rs11195418 decreased it (OR: 0.62; p = 0.025). The associations remained significant after adjustment for maternal age, maternal BMI, parity and a genetic risk score that included variants previously associated with Type 2 diabetes mellitus and GDM. CONCLUSION:ADRA2A genetic variation contributes independently to the risk of GDM in Caucasian women.
Authors: Abiodun Adefurin; Leon Darghosian; Chimalum Okafor; Vivian Kawai; Chun Li; Anushi Shah; Wei-Qi Wei; Daniel Kurnik; C Michael Stein Journal: Int J Cardiol Date: 2016-04-13 Impact factor: 4.164
Authors: Sarah D Linnstaedt; Margaret G Walker; Kyle D Riker; Jennifer E Nyland; JunMei Hu; Catherine Rossi; Robert A Swor; Jeffrey S Jones; Luda Diatchenko; Andrey V Bortsov; David A Peak; Samuel A McLean Journal: Pain Date: 2017-02 Impact factor: 7.926