Claudio Zett1,2, Luiz H Lima1, Silvana Vianello1, Adriano Ferreira1, Gabriel Costa de Andrade1,3, Michel E Farah1,3, Rubens Belfort1,3. 1. a Department of Ophthalmology and Visual Science - Paulista School of Medicine , Federal University of São Paulo (UNIFESP) , São Paulo , Brazil. 2. b Department of Ophthalmology, Pontificia Universidad Católica de Valparaíso , Valparaíso , Chile. 3. c Department of Ophthalmology, Instituto da Visão - IPEPO , São Paulo , Brazil.
Abstract
PURPOSE: To report a unique case series of acute syphilitic posterior placoid chorioretinopathy (ASPPC) correlating en-face optical coherence tomography (OCT) with standard imaging modalities. METHODS: In this retrospective case series, multimodal imaging was performed in three ASPPC patients at the time of disease presentation. RESULTS: Clinical and laboratory findings were consistent with the diagnosis of ASPPC. In all the study patients, multiple hyperreflective dot-like lesions distributed in the macular area and observed with en-face OCT at the level of retinal pigment epithelium (RPE) corresponded to the nodular RPE elevations on cross-sectional OCT and to the hyperautofluorescent spots on fundus autofluorescence. In addition, the cross-sectional OCT scans showed disorganization of the outer retinal bands and punctate choroidal hyperreflectivity. CONCLUSION: By combining en-face OCT with multimodal imaging analysis, we propose that a primary inflammation at the level of the choroid may be the pathogenic mechanism for the occurrence of outer retinal band abnormalities.
PURPOSE: To report a unique case series of acute syphilitic posterior placoid chorioretinopathy (ASPPC) correlating en-face optical coherence tomography (OCT) with standard imaging modalities. METHODS: In this retrospective case series, multimodal imaging was performed in three ASPPC patients at the time of disease presentation. RESULTS: Clinical and laboratory findings were consistent with the diagnosis of ASPPC. In all the study patients, multiple hyperreflective dot-like lesions distributed in the macular area and observed with en-face OCT at the level of retinal pigment epithelium (RPE) corresponded to the nodular RPE elevations on cross-sectional OCT and to the hyperautofluorescent spots on fundus autofluorescence. In addition, the cross-sectional OCT scans showed disorganization of the outer retinal bands and punctate choroidal hyperreflectivity. CONCLUSION: By combining en-face OCT with multimodal imaging analysis, we propose that a primary inflammation at the level of the choroid may be the pathogenic mechanism for the occurrence of outer retinal band abnormalities.
Authors: Katherine S Hu; Albert T Vitale; Akbar Shakoor; Marissa Larochelle; Therese Sassalos; Susan G Elner; Thiran Jayasundera; Christopher D Conrady Journal: Ophthalmol Retina Date: 2021-07-02