Lorenzo Fornaro1, Valentina Fanotto2, Gianna Musettini1, Mario Uccello3, Lorenza Rimassa4, Caterina Vivaldi1, Caterina Fontanella2, Francesco Leone5, Riccardo Giampieri6, Gerardo Rosati7, Monica Lencioni1, Daniele Santini8, Samantha Di Donato9, Gianluca Tomasello10, Oronzo Brunetti11, Filippo Pietrantonio12, Francesca Bergamo13, Mario Scartozzi14, Antonio Avallone15, Stefania Eufemia Lutrino16, Davide Melisi17, Lorenzo Antonuzzo18, Antonio Pellegrino19, Lorenzo Gerratana2, Stefano Cordio3, Enrico Vasile1, Giuseppe Aprile2,20. 1. Unit of Medical Oncology 2-Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy. 2. Department of Oncology, University & General Hospital, 33100 Udine, Italy. 3. Department of Oncology, Garibaldi Nesima Hospital, 95122 Catania, Italy. 4. Medical Oncology & Hematology Unit, Humanitas Cancer Center, Humanitas Clinical & Research Center, 20089 Rozzano (MI), Italy. 5. Institute for Cancer Research & Treatment, IRCCS, 10060 Candiolo (TO), Italy. 6. Unit of Medical Oncology, Ospedali Riuniti, 60126 Ancona, Italy. 7. Unit of Medical Oncology, San Carlo Hospital, 85100 Potenza, Italy. 8. Medical Oncology, Campus Biomedico University, 00128 Roma, Italy. 9. Department of Medical Oncology, General Hospital, 59100 Prato, Italy. 10. Medical Oncology Division, Istituti Ospitalieri di Cremona, 26100 Cremona, Italy. 11. Unit of Medical Oncology, National Cancer Institute IRCCS "Giovanni Paolo II", 70124 Bari, Italy. 12. Medical Oncology, National Cancer Institute IRCCS, 20133 Milano, Italy. 13. Medical Oncology, IOV IRCCS, 35128 Padova, Italy. 14. Unit of Medical Oncology, University Hospital, University of Cagliari, 09124 Cagliari, Italy. 15. Gastrointestinal Oncology, National Cancer Institute, IRCCS "Fondazione G. Pascale", 80131 Napoli, Italy. 16. Unit of Medical Oncology, Perrino Hospital, 72100 Brindisi, Italy. 17. Unit of Medical Oncology, University of Verona, 37126 Verona, Italy. 18. Unit of Medical Oncology, Careggi University Hospital, 50134 Firenze, Italy. 19. Unit of Oncology, Vito Fazzi Hospital, 73100 Lecce, Italy. 20. Department of Oncology, San Bortolo General Hospital, ULSS 8 Berica-East District, 36100 Vicenza, Italy.
Abstract
AIM: To evaluate the impact on overall survival (OS) of gastrectomy in asymptomatic metastatic esophago-gastric cancer. PATIENTS & METHODS: Five hundred and thirteen patients were included. The role of surgery and other clinico-pathological factors was evaluated by univariate and Cox regression analyses. OS was the primary end point. RESULTS: Multivariate analysis confirmed that gastrectomy was a predictor of longer OS (p < 0.001), as well as preserved performance status and benefit from first-line chemotherapy. None of the investigated clinico-pathological variables identified preferable candidates for surgery (all p > 0.05). CONCLUSION: Palliative gastrectomy might play a role in asymptomatic metastatic esophago-gastric cancer patients with good performance status who received benefit from first-line chemotherapy. Future prospective trials integrating tumor biology among inclusion criteria may help defining the optimal candidates.
AIM: To evaluate the impact on overall survival (OS) of gastrectomy in asymptomatic metastatic esophago-gastric cancer. PATIENTS & METHODS: Five hundred and thirteen patients were included. The role of surgery and other clinico-pathological factors was evaluated by univariate and Cox regression analyses. OS was the primary end point. RESULTS: Multivariate analysis confirmed that gastrectomy was a predictor of longer OS (p < 0.001), as well as preserved performance status and benefit from first-line chemotherapy. None of the investigated clinico-pathological variables identified preferable candidates for surgery (all p > 0.05). CONCLUSION: Palliative gastrectomy might play a role in asymptomatic metastatic esophago-gastric cancerpatients with good performance status who received benefit from first-line chemotherapy. Future prospective trials integrating tumor biology among inclusion criteria may help defining the optimal candidates.
Authors: Marcus Fernando Kodama Pertille Ramos; Marina Alessandra Pereira; André Roncon Dias; Tiago Biachi de Castria; Erica Sakamoto; Ulysses Ribeiro-Jr; Bruno Zilberstein; Sérgio Carlos Nahas Journal: Arq Bras Cir Dig Date: 2022-06-17
Authors: Joseph Cowling; Bethany Gorman; Afrah Riaz; James R Bundred; Sivesh K Kamarajah; Richard P T Evans; Pritam Singh; Ewen A Griffiths Journal: J Gastrointest Cancer Date: 2020-09-22