Literature DB >> 28975544

The role of α9β1 integrin and its ligands in the development of autoimmune diseases.

Shigeyuki Kon1, Toshimitsu Uede2.   

Abstract

Adhesion of cells to extracellular matrix proteins through integrins expressed on the cell surface is important for cell adhesion/motility, survival, and differentiation. Recently, α9β1 integrin was reported to be important for the development of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, and their murine models. In addition, ligands for α9β1 integrin, such as osteopontin and tenascin-C, are well established as key regulators of autoimmune diseases. Therefore, this review focused on the role of interactions between α9β1 integrin and its ligands in the development of autoimmune diseases.

Entities:  

Keywords:  Autoimmune diseases; Multiple sclerosis; Osteopontin; Rheumatoid arthritis; Tenascin-C; α9 integrin

Year:  2017        PMID： 28975544      PMCID： PMC5842177          DOI： 10.1007/s12079-017-0413-7

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  84 in total

1.  Tissue transglutaminase, coagulation factor XIII, and the pro-polypeptide of von Willebrand factor are all ligands for the integrins alpha 9beta 1 and alpha 4beta 1.

Authors:  H Takahashi; T Isobe; S Horibe; J Takagi; Y Yokosaki; D Sheppard; Y Saito
Journal:  J Biol Chem       Date:  2000-08-04       Impact factor: 5.157

2.  Role of osteopontin in synovial Th17 differentiation in rheumatoid arthritis.

Authors:  Guangjie Chen; Xin Zhang; Runsheng Li; Lei Fang; Xiaoyin Niu; Yingxia Zheng; Dongyi He; Rong Xu; Jingwu Z Zhang
Journal:  Arthritis Rheum       Date:  2010-10

3.  The spatial and temporal expression patterns of integrin alpha9beta1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing.

Authors:  Purva Singh; Corinne L Reimer; John H Peters; Mary Ann Stepp; Richard O Hynes; Livingston Van De Water
Journal:  J Invest Dermatol       Date:  2004-12       Impact factor: 8.551

4.  Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease.

Authors:  Kim Midwood; Sandra Sacre; Anna M Piccinini; Julia Inglis; Annette Trebaul; Emma Chan; Stefan Drexler; Nidhi Sofat; Masahide Kashiwagi; Gertraud Orend; Fionula Brennan; Brian Foxwell
Journal:  Nat Med       Date:  2009-06-28       Impact factor: 53.440

Review 5.  Integrins: a family of cell surface receptors.

Authors:  R O Hynes
Journal:  Cell       Date:  1987-02-27       Impact factor: 41.582

6.  The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1.

Authors:  Nicholas E Vlahakis; Bradford A Young; Amha Atakilit; Dean Sheppard
Journal:  J Biol Chem       Date:  2004-12-06       Impact factor: 5.157

7.  α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation.

Authors:  Masashi Kanayama; Junko Morimoto; Yutaka Matsui; Masahiro Ikesue; Keiko Danzaki; Daisuke Kurotaki; Koyu Ito; Toshimichi Yoshida; Toshimitsu Uede
Journal:  J Immunol       Date:  2011-10-28       Impact factor: 5.422

8.  Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function.

Authors:  Hongwei Rao; Ganwei Lu; Hiroshi Kajiya; Veronica Garcia-Palacios; Noriyoshi Kurihara; Judy Anderson; Ken Patrene; Dean Sheppard; Harry C Blair; Jolene J Windle; Sun Jin Choi; G David Roodman
Journal:  J Bone Miner Res       Date:  2006-10       Impact factor: 6.741

9.  Integrin alpha9 beta1 is a receptor for nerve growth factor and other neurotrophins.

Authors:  Izabela Staniszewska; Ilker K Sariyer; Shimon Lecht; Meghan C Brown; Erin M Walsh; George P Tuszynski; Mahmut Safak; Philip Lazarovici; Cezary Marcinkiewicz
Journal:  J Cell Sci       Date:  2008-01-29       Impact factor: 5.285

10.  Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY.

Authors:  B M Chan; M J Elices; E Murphy; M E Hemler
Journal:  J Biol Chem       Date:  1992-04-25       Impact factor: 5.157
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  10 in total

1.  Tenascin-C Promotes Tumor Cell Migration and Metastasis through Integrin α9β1-Mediated YAP Inhibition.

Authors:  Zhen Sun; Anja Schwenzer; Tristan Rupp; Devadarssen Murdamoothoo; Rolando Vegliante; Olivier Lefebvre; Annick Klein; Thomas Hussenet; Gertraud Orend
Journal:  Cancer Res       Date:  2017-12-19       Impact factor: 12.701

2.  Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation.

Authors:  Nirav Dhanesha; Manish Jain; Amit K Tripathi; Prakash Doddapattar; Mehul Chorawala; Girish Bathla; Manasa K Nayak; Madankumar Ghatge; Steven R Lentz; Shigeyuki Kon; Anil K Chauhan
Journal:  Circ Res       Date:  2020-03-20       Impact factor: 17.367

3.  Abnormal promoter DNA hypermethylation of the integrin, nidogen, and dystroglycan genes in breast cancer.

Authors:  Vladimir V Strelnikov; Ekaterina B Kuznetsova; Alexander S Tanas; Viktoria V Rudenko; Alexey I Kalinkin; Elena V Poddubskaya; Tatiana V Kekeeva; Galina G Chesnokova; Ivan D Trotsenko; Sergey S Larin; Sergey I Kutsev; Dmitry V Zaletaev; Marina V Nemtsova; Olga A Simonova
Journal:  Sci Rep       Date:  2021-01-26       Impact factor: 4.379

Review 4.  Integrin-α9β1 as a Novel Therapeutic Target for Refractory Diseases: Recent Progress and Insights.

Authors:  Shihan Xu; Tingwei Zhang; Zhengguo Cao; Wenjie Zhong; Chuangwei Zhang; Han Li; Jinlin Song
Journal:  Front Immunol       Date:  2021-03-15       Impact factor: 7.561

5.  Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis.

Authors:  Chaim Gilon; Michal Klazas; Adi Lahiani; Adi Schumacher-Klinger; Shira Merzbach; Johnny N Naoum; Haim Ovadia; Limor Rubin; Susan Cornell-Kennon; Erik M Schaefer; Jehoshua Katzhendler; Cezary Marcinkiewicz; Amnon Hoffman; Philip Lazarovici
Journal:  JACS Au       Date:  2021-11-24

Review 6.  Role of Integrins in Modulating Smooth Muscle Cell Plasticity and Vascular Remodeling: From Expression to Therapeutic Implications.

Authors:  Manish Jain; Anil K Chauhan
Journal:  Cells       Date:  2022-02-13       Impact factor: 6.600

7.  Different Spatial and Temporal Roles of Monocytes and Monocyte-Derived Cells in the Pathogenesis of an Imiquimod Induced Lupus Model.

Authors:  Atsushi Nomura; Miho Mizuno; Daisuke Noto; Aki Aoyama; Taiga Kuga; Goh Murayama; Asako Chiba; Sachiko Miyake
Journal:  Front Immunol       Date:  2022-03-15       Impact factor: 7.561

8.  Integrin α9 regulates smooth muscle cell phenotype switching and vascular remodeling.

Authors:  Manish Jain; Rishabh Dev; Prakash Doddapattar; Shigeyuki Kon; Nirav Dhanesha; Anil K Chauhan
Journal:  JCI Insight       Date:  2021-05-24

9.  Localization of integrin heterodimer α9β1 on the surface of uterine endometrial stromal and epithelial cells in mice.

Authors:  Hye Jin Park; Jung Im Yun; Seung Tae Lee
Journal:  Anim Cells Syst (Seoul)       Date:  2020-08-05       Impact factor: 1.815

10.  VCAM1-α4β1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells.

Authors:  Kazuko Abe; Shigeyuki Kon; Hiroki Kameyama; JiDong Zhang; Ken-Ichirou Morohashi; Kenji Shimamura; Shin-Ichi Abe
Journal:  Sci Rep       Date:  2021-09-15       Impact factor: 4.379
  10 in total

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