| Literature DB >> 2897518 |
M Helbert1, D Robinson, B Peddle, S Forster, A Kocsis, D Jeffries, A J Pinching.
Abstract
In a study of treatment by zidovudine in 106 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex, an acute meningo-encephalitic illness developed in 4 of 21 patients within 17 days after the dose of zidovudine had had to be reduced because of myelotoxicity. 3 of the 4 patients had previous clinical evidence of HIV encephalopathy. AIDS-related opportunist infection of the central nervous system was excluded. This acute meningo-encephalitic illness probably results from an increase in HIV replication following dose reduction.Entities:
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Year: 1988 PMID： 2897518 DOI： 10.1016/s0140-6736(88)92072-7
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321