Literature DB >> 28975113

Testicular metastasis in Wilms' tumor.

Shikha Dhal1, Maitrik J Mehta1, Ankita Parikh1, Maitri Bhagat1, Aryakumar Banidutta1.   

Abstract

Entities:  

Year:  2017        PMID: 28975113      PMCID: PMC5615874          DOI: 10.4103/sajc.sajc_85_17

Source DB:  PubMed          Journal:  South Asian J Cancer        ISSN: 2278-330X


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Dear Editor, We report a rare case of a 2-year-old male child with Wilms’ tumor with unusual left testicular metastasis. The patient presented with fever, pain abdomen, and left flank mass of approximate size 8.0 cm × 8.0 cm, of 7 months duration. Computed tomography (CT) scan revealed a 7.8 cm × 7.0 cm × 7.8 cm mass in the left kidney. He underwent left radical nephrectomy in August 2015 and final diagnosis was stage I with tumor size of 8.0 cm × 6.5 cm, favorable histology, and with blastemal component on histopathology report. He received five cycles vincristine and cyclophosphamide-based adjuvant chemotherapy at another hospital. In June 2016, he presented with 7.6 cm × 8.6 cm × 9.6 cm retroperitoneal mass with multiple lung metastasis. The boy was given salvage chemotherapy with alternating cycles of cyclophosphamide, etoposide and doxorubicin, and vincristine for two cycles. CT scan at the end of salvage chemotherapy shows complete resolution of lung metastasis and retroperitoneal mass remained unchanged. He received 21.6 Gy/12 fractions to local disease and 12 Gy/8 fractions as lung bath. One month later, a left testicular swelling was detected. Ultrasonography (USG) done in August 2016 showed left testicular mass of size 2.7 cm × 2.6 cm with heterogeneous enhancement. Fine-needle aspiration cytology from testicular mass confirmed metastatic Wilms’ tumor. Patient was then given radiotherapy (10.8 Gy/6 fractions) to scrotum in August 2016. USG of scrotum showed decrease in the mass up to 2 cm × 1.6 cm (partial response). Additional radiotherapy of 19.8 Gy was given followed by chemotherapy (ifosfamide, carboplatin, and etoposide). This is an interesting case since testicular metastasis in Wilms’ tumor is rare, ipsilateral spread can be caused through spermatic vein, and use or radiation therapy is feasible (with partial response) even after multiple recurrences.[123] It also teaches us that retrograde venous and transcoelomic spread may potentially be prevented by spermatic vein ligation immediately before nephrectomy.

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  2 in total

Review 1.  Paratesticular metastasis from Wilms tumor: the possible routs of metastasis and literature review.

Authors:  Abdol-Mohammad Kajbafzadeh; Niloufar Javan-Farazmand; Arash Baghayee; Zeinab Hedayat
Journal:  J Pediatr Hematol Oncol       Date:  2011-12       Impact factor: 1.289

2.  Bilateral wilms' tumor metastasis to right spermatic cord.

Authors:  Shahla Ansari; Ghasem Miri-Aliabad; Naser Rakhshani
Journal:  Int J Hematol Oncol Stem Cell Res       Date:  2013
  2 in total

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