Literature DB >> 28973416

The Molecular Design Research Network.

Philip Coish1, Bryan W Brooks2,3, Evan P Gallagher4, Margaret Mills4, Terrance J Kavanagh4, Nancy Simcox4, Grace A Lasker4, Dianne Botta4, Stephanie C Schmuck4, Adelina Voutchkova-Kostal5, Jakub Kostal5, Melissa L Mullins3, Suzanne M Nesmith6, Karolina E Mellor1, Jone Corrales2,3, Lauren A Kristofco2,3, Gavin N Saari2,3, Baylor Steele2,3, Longzhu Q Shen1, Fjodor Melnikov1, Julie B Zimmerman1,7, Paul T Anastas1,7.   

Abstract

Herein, we provide an overview of a research network that is aimed at fostering interdisciplinary collaboration between chemists and toxicologists with the goal of rationally designing safer commercial chemicals. The collaborative is the Molecular Design Research Network (MoDRN) that was created in 2013 with funding from the EPA-National Science Foundation Networks for Sustainable Molecular Design and Synthesis (NSMDS) program. MoDRN is led by 4 universities, Baylor University, University of Washington, The George Washington University, and Yale University. The overarching goal of the network is to enable and empower the design of safer chemicals based on the fourth Principle of Green Chemistry that states, "chemical products should be designed to preserve efficacy of function while minimizing toxicity."
© The Author 2017. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  computational methods; green chemistry; guidelines; in silico models; molecular design; molecular properties; nexus; safer chemical design; systems thinking; toxicology

Mesh:

Year:  2018        PMID: 28973416     DOI: 10.1093/toxsci/kfx175

Source DB:  PubMed          Journal:  Toxicol Sci        ISSN: 1096-0929            Impact factor:   4.849


  5 in total

1.  A Farewell to Harms: The Audacity to Design Safer Products.

Authors:  Nicholas Anastas; Gary W Miller
Journal:  Toxicol Sci       Date:  2018-02-01       Impact factor: 4.849

2.  Application of the hard and soft, acids and bases (HSAB) theory as a method to predict cumulative neurotoxicity.

Authors:  Fjodor Melnikov; Brian C Geohagen; Terrence Gavin; Richard M LoPachin; Paul T Anastas; Phillip Coish; David W Herr
Journal:  Neurotoxicology       Date:  2020-05-05       Impact factor: 4.294

3.  Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in Vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis.

Authors:  Fjodor Melnikov; Dianne Botta; Collin C White; Stefanie C Schmuck; Matthew Winfough; Christopher M Schaupp; Evan P Gallagher; Bryan W Brooks; Edward Spencer Williams; Philip Coish; Paul T Anastas; Adelina Voutchkova-Kostal; Jakub Kostal; Terrance J Kavanagh
Journal:  Chem Res Toxicol       Date:  2019-01-07       Impact factor: 3.739

4.  Structure-to-process design framework for developing safer pesticides.

Authors:  Jessica M Lewer; Zachary R Stickelman; Jessica H Huang; John F Peloquin; Jakub Kostal
Journal:  Sci Adv       Date:  2022-03-30       Impact factor: 14.136

5.  Urbanization, environment and pharmaceuticals: advancing comparative physiology, pharmacology and toxicology.

Authors:  Bryan W Brooks
Journal:  Conserv Physiol       Date:  2018-01-17       Impact factor: 3.079

  5 in total

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