Danièlle Gunn-Moore1, Oksana Kaidanovich-Beilin2, María Carolina Gallego Iradi3, Frank Gunn-Moore4, Simon Lovestone5. 1. University of Edinburgh, Royal (Dick) School of Veterinary Studies and The Roslin Institute, Easter Bush Campus, Roslin, UK. 2. AstraZeneca Canada, Mississauga, Ontario, Canada. 3. University of Florida, College of Medicine, Department of Neuroscience, Center for Translational Research in Neurodegenerative Diseases, Gainesville, FL, USA. 4. University of St Andrews, School of Biology, St Andrews, UK. 5. University of Oxford, Department of Psychiatry, Oxford, UK. Electronic address: simon.lovestone@psych.ox.ac.uk.
Abstract
INTRODUCTION: Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading to speculation that caloric restriction might extend life span in man. It is our contention that man is already a long-lived organism, specifically with a remarkably high postfertility life span, and that it is this that results in the prevalence of Alzheimer's disease and diabetes. METHODS: We review evidence for this hypothesis that carries specific predictions including that other animals with exceptionally long postreproductive life span will have increased risk of both diabetes and Alzheimer's disease. RESULTS AND CONCLUSIONS: We present novel evidence that Dolphin, like man, an animal with exceptional longevity, might be one of the very few natural models of Alzheimer's disease.
INTRODUCTION:Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading to speculation that caloric restriction might extend life span in man. It is our contention that man is already a long-lived organism, specifically with a remarkably high postfertility life span, and that it is this that results in the prevalence of Alzheimer's disease and diabetes. METHODS: We review evidence for this hypothesis that carries specific predictions including that other animals with exceptionally long postreproductive life span will have increased risk of both diabetes and Alzheimer's disease. RESULTS AND CONCLUSIONS: We present novel evidence that Dolphin, like man, an animal with exceptional longevity, might be one of the very few natural models of Alzheimer's disease.
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