| Literature DB >> 28972755 |
Tiphaine Péresse1, Gwenaëlle Jézéquel1, Pierre-Marie Allard2, Van-Cuong Pham3, Doan T M Huong3, Florent Blanchard1, Jérôme Bignon1, Hélène Lévaique1, Jean-Luc Wolfender2, Marc Litaudon1, Fanny Roussi1.
Abstract
With the aim of discovering new cytotoxic prenylated stilbenes of the schweinfurthin series, Macaranga tanarius was selected for detailed phytochemical investigation among 21 Macaranga species examined by using a molecular networking approach. From an ethanol extract of the fruits, seven new prenylated stilbenes, schweinfurthins K-Q (7-13), were isolated, along with vedelianin (1), schwenfurthins E-G (2-4), mappain (5), and methyl-mappain (6). The structures of the new compounds were established by spectroscopic data analysis. The relative configurations of compounds 8, 12, and 13 were determined based on ROESY NMR spectroscopic analysis. The cytotoxic activities of compounds 1-13 were evaluated against the human glioblastoma (U87) and lung (A549) cancer cell lines.Entities:
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Year: 2017 PMID： 28972755 DOI： 10.1021/acs.jnatprod.7b00409
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050