Luke Martin1, William Peche1, Kathryn Peterson2, Yuan Wan3, Stephanie Chan2, Ryan Morton2, Chong Zhang4, Angela P Presson4, James Hotaling1,5. 1. Department of Surgery, School of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. 2. Division of Gastroenterology, School of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. 3. Utah Population Database, University of Utah, Huntsman Cancer Institute, Salt Lake City, Utah, USA. 4. Division of Epidemiology, School of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. 5. Division of Urology, School of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Abstract
OBJECTIVES: Crohn's disease (CD) and ulcerative colitis (UC) impact an estimated 350,000 reproductive age men in the United States. The reproductive consequences are largely unknown. The objective of this study was to evaluate the effects of CD and UC on reproductive outcomes. METHODS: From the Utah Population Database, we identified a cohort of male patients with CD (1,245) and UC (1,368). Male-sibling controls were identified, and birth outcome data from offspring were obtained. Analyses for CD and UC were completed separately. RESULTS: Among UC patients (473) with at least one male sibling (1,020), 66% had offspring, which was not different compared with siblings (61%, P=0.16). Birth outcomes were not different between UC patients and male siblings: congenital malformations (UC 6% vs. 6%, P=0.99), perinatal complications (UC 35% vs. 31%, P=0.23), mean birth weight (UC 3,347 vs. 3,357 g, P=0.53), mean length of gestation (UC 39.0 vs. 39.1 weeks, P=0.54). Among CD patients (421) with at least one male sibling (833), 58% had offspring, which did not differ compared with siblings (57%, P=0.77). Similarly, there were no differences in partner birth outcomes: congenital malformations (CD 7% vs. 6%, P=0.27), perinatal complications (CD 35% vs. 32%, P=0.12), mean birth weight (CD 3,276 vs. 3,324 g, P=0.13), or mean length of gestation (38.8 vs. 39 weeks, P=0.24). CONCLUSIONS: We found no differences in paternity rate or female partner birth outcomes in Utah men with UC or CD compared with male-sibling controls. UC and CD do not appear to affect the reproductive outcomes of men in Utah.
OBJECTIVES:Crohn's disease (CD) and ulcerative colitis (UC) impact an estimated 350,000 reproductive age men in the United States. The reproductive consequences are largely unknown. The objective of this study was to evaluate the effects of CD and UC on reproductive outcomes. METHODS: From the Utah Population Database, we identified a cohort of male patients with CD (1,245) and UC (1,368). Male-sibling controls were identified, and birth outcome data from offspring were obtained. Analyses for CD and UC were completed separately. RESULTS: Among UC patients (473) with at least one male sibling (1,020), 66% had offspring, which was not different compared with siblings (61%, P=0.16). Birth outcomes were not different between UC patients and male siblings: congenital malformations (UC 6% vs. 6%, P=0.99), perinatal complications (UC 35% vs. 31%, P=0.23), mean birth weight (UC 3,347 vs. 3,357 g, P=0.53), mean length of gestation (UC 39.0 vs. 39.1 weeks, P=0.54). Among CDpatients (421) with at least one male sibling (833), 58% had offspring, which did not differ compared with siblings (57%, P=0.77). Similarly, there were no differences in partner birth outcomes: congenital malformations (CD 7% vs. 6%, P=0.27), perinatal complications (CD 35% vs. 32%, P=0.12), mean birth weight (CD 3,276 vs. 3,324 g, P=0.13), or mean length of gestation (38.8 vs. 39 weeks, P=0.24). CONCLUSIONS: We found no differences in paternity rate or female partner birth outcomes in Utah men with UC or CD compared with male-sibling controls. UC and CD do not appear to affect the reproductive outcomes of men in Utah.
Authors: Séverine Vermeire; Franck Carbonnel; Pierre G Coulie; Vincent Geenen; Johanna M W Hazes; Pierre L Masson; Filip De Keyser; Edouard Louis Journal: J Crohns Colitis Date: 2012-05-16 Impact factor: 9.071
Authors: Willem E Hueting; Erik Buskens; Ingeborg van der Tweel; Hein G Gooszen; Cees J H M van Laarhoven Journal: Dig Surg Date: 2005-04-14 Impact factor: 2.588