Scott Poh1, Venkatesh Chelvam2, Lindsay E Kelderhouse3, Wilfredo Ayala-López4, Balasubramanian Vaitilingam3, Karson S Putt5, Philip S Low3,5. 1. College of Engineering & Science, Louisiana Tech University, Ruston, LA 71272, USA. 2. Department of Chemistry, Centre for Biosciences & Biomedical Engineering, Indian Institute of Technology, Indore, 453 552 Madhya Pradesh, India. 3. Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. 4. Department of Biology, University of Puerto Rico, Ponce, PA 00716, USA. 5. Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.
Abstract
AIM: We endeavored to create a folate-targeted liposome (Fol-liposome) that could selectively target areas of inflammation. MATERIALS & METHODS: Fol-liposomes were prepared with encapsulated DiD fluorophore or betamethasone (BM) to image and treat an adjuvant-induced rat model of rheumatoid arthritis. RESULTS: Fol-liposomes selectively accumulated in arthritic rat paws to a greater extent than nontargeted liposomes. When these Fol-liposomes were used to encapsulate BM and administered to arthritic rats, animals exhibited less paw swelling, lower arthritis scores, a reduction in bone erosion, less splenomegaly and better maintenance of body weight when compared with nontreated or nontargeted BM-containing liposome groups. CONCLUSION: Fol-liposomes can selectively deliver imaging and therapeutic agents to sites of inflammation in a rat model of rheumatoid arthritis.
AIM: We endeavored to create a folate-targeted liposome (Fol-liposome) that could selectively target areas of inflammation. MATERIALS & METHODS: Fol-liposomes were prepared with encapsulated DiD fluorophore or betamethasone (BM) to image and treat an adjuvant-induced rat model of rheumatoid arthritis. RESULTS: Fol-liposomes selectively accumulated in arthritic rat paws to a greater extent than nontargeted liposomes. When these Fol-liposomes were used to encapsulate BM and administered to arthritic rats, animals exhibited less paw swelling, lower arthritis scores, a reduction in bone erosion, less splenomegaly and better maintenance of body weight when compared with nontreated or nontargeted BM-containing liposome groups. CONCLUSION: Fol-liposomes can selectively deliver imaging and therapeutic agents to sites of inflammation in a rat model of rheumatoid arthritis.
Authors: Rakeshchandra R Meka; Shivaprasad H Venkatesha; Bodhraj Acharya; Kamal D Moudgil Journal: Nanomedicine (Lond) Date: 2019-04-02 Impact factor: 5.307
Authors: Yingwen Hu; Bingbing Wang; Jiayin Shen; Stewart A Low; Karson S Putt; Hans W M Niessen; Eric L Matteson; Linda Murphy; Clemens Ruppert; Gerrit Jansen; Stephen J Oliver; Yang Feng; Dimiter S Dimitrov; Cheryl Nickerson-Nutter; Philip S Low Journal: Arthritis Res Ther Date: 2019-06-07 Impact factor: 5.156