| Literature DB >> 28972371 |
Li Fu, Kevin Li, Daisuke Mori, Makoto Hirakane, Lei Lin, Navdeep Grover, Payel Datta, Yanlei Yu, Jing Zhao, Fuming Zhang, Murat Yalcin1,2, Shaker A Mousa1, Jonathan S Dordick, Robert J Linhardt.
Abstract
Unlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1, -3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.Entities:
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Year: 2017 PMID： 28972371 DOI： 10.1021/acs.jmedchem.7b01269
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446