Literature DB >> 28970715

Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases.

Narendra S Choudhary1, Vijay Bodh2, Shraddha Chaudhari3, Neeraj Saraf1, Sanjiv Saigal1.   

Abstract

Drug induced liver injury (DILI) is uncommon and severe forms are associated with significant morbidity and mortality. Female sex hormones (estrogens and progestogens) related DILI generally occur with estrogen component. Progesterone component related DILI are infrequently reported. Norethisterone is commonly used drug in gynecologic practice to prevent excess per vaginal bleeding. We report 3 cases of Norethisterone related DILI manifesting as significant rise of transaminases. All of these patients took Norethisterone for prolonged periods and improved completely after withdrawal of drug.

Entities:  

Keywords:  ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; DILI, drug induced liver injury; Norethisterone; ULN, upper limit of normal; drug induced liver injury; progestogens; sex hormones

Year:  2017        PMID： 28970715      PMCID： PMC5620103          DOI： 10.1016/j.jceh.2017.01.001

Source DB:  PubMed          Journal:  J Clin Exp Hepatol        ISSN： 0973-6883


  12 in total

1.  Cytolytic hepatitis possibly related to levonorgestrel/ethinylestradiol oral contraceptive use: 2 case reports.

Authors:  Bouraoui Elouni; Chaker Ben Salem; Michele Zamy; Nathalie Ganne; Michel Beaugrand; Kamel Bouraoui; Michel Biour
Journal:  Ann Pharmacother       Date:  2010-11-30       Impact factor: 3.154

Review 2.  Choosing a combined oral contraceptive pill.

Authors:  Mary Stewart; Kirsten Black
Journal:  Aust Prescr       Date:  2015-02-02

3.  Norethisterone-induced cholestasis.

Authors:  V Anand; D A Gorard
Journal:  QJM       Date:  2005-03

4.  Letter: Jaundice associated with norethisterone-acetate treatment of breast cancer.

Authors:  A O Langlands; W M Martin
Journal:  Lancet       Date:  1975-03-08       Impact factor: 79.321

5.  Progesterone metabolites and bile acids in serum of patients with intrahepatic cholestasis of pregnancy: effect of ursodeoxycholic acid therapy.

Authors:  L J Meng; H Reyes; M Axelson; J Palma; I Hernandez; J Ribalta; J Sjövall
Journal:  Hepatology       Date:  1997-12       Impact factor: 17.425

6.  Progesterone in Peri- and Postmenopause: A Review.

Authors:  P-A Regidor
Journal:  Geburtshilfe Frauenheilkd       Date:  2014-11       Impact factor: 2.915

7.  Severe and prolonged oral contraceptive jaundice.

Authors:  D A Lieberman; E B Keeffe; P Stenzel
Journal:  J Clin Gastroenterol       Date:  1984-04       Impact factor: 3.062

8.  Androgenic/Anabolic steroid-induced toxic hepatitis.

Authors:  Davor Stimac; Sandra Milić; Renata Dobrila Dintinjana; Drazen Kovac; Smiljana Ristić
Journal:  J Clin Gastroenterol       Date:  2002-10       Impact factor: 3.062

9.  Oral contraceptives and hepatitis. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center.

Authors:  A S Morrison; H Jick; H W Ory
Journal:  Lancet       Date:  1977-05-28       Impact factor: 79.321

Review 10.  An Update on Treatment of Drug-Induced Liver Injury.

Authors:  Christin Giordano; John Rivas; Xaralambos Zervos
Journal:  J Clin Transl Hepatol       Date:  2014-06-15
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  3 in total

Review 1.  The Hepatoprotective and Hepatotoxic Roles of Sex and Sex-Related Hormones.

Authors:  Linlin Xu; Yuan Yuan; Zhaodi Che; Xiaozhi Tan; Bin Wu; Cunchuan Wang; Chengfang Xu; Jia Xiao
Journal:  Front Immunol       Date:  2022-07-04       Impact factor: 8.786

Review 2.  Drug-Induced Liver Injury: Highlights of the Recent Literature.

Authors:  Mark Real; Michele S Barnhill; Cory Higley; Jessica Rosenberg; James H Lewis
Journal:  Drug Saf       Date:  2019-03       Impact factor: 5.606

3.  Rare case of norethisterone-induced hepatitis: A case report.

Authors:  Eiman A Arafa; Vasumathi Dhayabaran; Nabil E Omar; Ahmed Awaisu
Journal:  Clin Case Rep       Date:  2022-04-08
  3 in total

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