Literature DB >> 28969870

SAMHD1 Sheds Moonlight on DNA Double-Strand Break Repair.

Maria Jose Cabello-Lobato1, Siyue Wang1, Christine Katrin Schmidt2.   

Abstract

SAMHD1 (sterile α motif and histidine (H) aspartate (D) domain-containing protein 1) is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks (DSBs) by promoting recruitment of C-terminal binding protein interacting protein (CTIP), a DNA-end resection factor, to damaged DNA. These findings could benefit anticancer treatment.
Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  CTIP; DNA double-strand breaks; DNA-end resection; SAMHD1; cancer; homologous recombination

Mesh：

Substances：

Year:  2017        PMID： 28969870     DOI： 10.1016/j.tig.2017.09.007

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  10 in total

1.  Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes.

Authors:  Dana Sherill-Rofe; Dolev Rahat; Steven Findlay; Anna Mellul; Irene Guberman; Maya Braun; Idit Bloch; Alon Lalezari; Arash Samiei; Ruslan Sadreyev; Michal Goldberg; Alexandre Orthwein; Aviad Zick; Yuval Tabach
Journal:  Genome Res       Date:  2019-02-04       Impact factor: 9.043

2.  Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics.

Authors:  Benjamin Orris; Kevin W Huynh; Mark Ammirati; Seungil Han; Ben Bolaños; Jason Carmody; Matthew D Petroski; Benedikt Bosbach; David J Shields; James T Stivers
Journal:  Nucleic Acids Res       Date:  2022-07-22       Impact factor: 19.160

Review 3.  Tetraspanins, Another Piece in the HIV-1 Replication Puzzle.

Authors:  Henar Suárez; Vera Rocha-Perugini; Susana Álvarez; María Yáñez-Mó
Journal:  Front Immunol       Date:  2018-08-03       Impact factor: 7.561

4.  SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes.

Authors:  Claire D James; Apurva T Prabhakar; Raymonde Otoa; Michael R Evans; Xu Wang; Molly L Bristol; Kun Zhang; Renfeng Li; Iain M Morgan
Journal:  mSphere       Date:  2019-08-07       Impact factor: 4.389

Review 5.  Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs.

Authors:  Zhangming Chen; Jie Hu; Songcheng Ying; Aman Xu
Journal:  Oncol Lett       Date:  2021-04-08       Impact factor: 2.967

6.  Modulation of DNA Damage Response by SAM and HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase (SAMHD1) Determines Prognosis and Treatment Efficacy in Different Solid Tumor Types.

Authors:  Eudald Felip; Lucía Gutiérrez-Chamorro; Maica Gómez; Edurne Garcia-Vidal; Margarita Romeo; Teresa Morán; Laura Layos; Laia Pérez-Roca; Eva Riveira-Muñoz; Bonaventura Clotet; Pedro Luis Fernandez; Ricard Mesía; Anna Martínez-Cardús; Ester Ballana; Mireia Margelí
Journal:  Cancers (Basel)       Date:  2022-01-27       Impact factor: 6.639

Review 7.  Activating the DNA Damage Response and Suppressing Innate Immunity: Human Papillomaviruses Walk the Line.

Authors:  Claire D James; Dipon Das; Molly L Bristol; Iain M Morgan
Journal:  Pathogens       Date:  2020-06-13

Review 8.  SAMHD1 Functions and Human Diseases.

Authors:  Si'Ana A Coggins; Bijan Mahboubi; Raymond F Schinazi; Baek Kim
Journal:  Viruses       Date:  2020-03-31       Impact factor: 5.048

9.  TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.

Authors:  Zhaolong Li; Chen Huan; Hong Wang; Yue Liu; Xin Liu; Xing Su; Jinghua Yu; Zhilei Zhao; Xiao-Fang Yu; Baisong Zheng; Wenyan Zhang
Journal:  EMBO Rep       Date:  2019-12-04       Impact factor: 8.807

Review 10.  SAMHD1 … and Viral Ways around It.

Authors:  Janina Deutschmann; Thomas Gramberg
Journal:  Viruses       Date:  2021-03-02       Impact factor: 5.048
  10 in total

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