Behshad Naghshtabrizi1, Abbas Moradi2, Jalaleddin Amiri3, Sepide Aarabi4, Zahra Sanaei5. 1. Associate Professor, Department of Cardiology, Hamadan University of Medical Sciences, Hamadan, Iran. 2. Epidemiologist, Department of Community Medicine, Hamadan University of Medical Science, Hamadan, Iran. 3. Assistant Professor, Deputy for Health, Department of Paediatrics, Hamadan University of Medical Science, Hamadan, Iran. 4. Consultant, Department of Cardiology, Hamadan University of Medical Science, Hamadan, Iran. 5. Community Medicine Specialist, Department of Community Medicine, Education Development Office, Hamadan University of Medical Science, Hamadan, Iran.
Abstract
INTRODUCTION: Despite definite recognition of major atherosclerotic risk factors, the relationship between the pattern of coronary artery disease and these risk factors is unknown. AIM: The aim of this study was to identify the relationship between some of the major atherosclerotic risk factors and the number and pattern of coronary artery disease in patients with coronary artery disease who presented to Farshchian Heart University Hospital, Hamadan, Iran. MATERIALS AND METHODS: In this descriptive cross-sectional study, we investigated some of the major atherosclerotic risk factors and their relationships with the type of coronary artery disease in terms of number and location of disease. A total of 1100 patients were enrolled with coronary artery disease confirmed by selective coronary angiography from 2010-2014. A p-value<0.05 was considered statistically significant. RESULTS: A total of 1100 patients enrolled in this study. The patient population consisted of 743 (67.5%) males and 357 (32.5%) females. A meaningful relationship existed between ageing, diabetes mellitus, hypertension and 3-Vessel Disease (3VD, p<0.001) as well as between hyperlipidemia and Single Vessel Disease (SVD, p<0.001). Patients diagnosed with diabetes mellitus, hypertension, and hyperlipidemia showed greater potential to develop coronary artery disease at the proximal section of the coronary arteries. CONCLUSION: Based on the relationship between some of the major risk factors and the pattern of coronary artery disease in the current study, prospective studies should investigate other risk factors. We recommend that a plan should be developed to reduce adjustable risk factors such as diabetes mellitus, hypertension and hyperlipidemia in order to decrease coronary artery disease.
INTRODUCTION: Despite definite recognition of major atherosclerotic risk factors, the relationship between the pattern of coronary artery disease and these risk factors is unknown. AIM: The aim of this study was to identify the relationship between some of the major atherosclerotic risk factors and the number and pattern of coronary artery disease in patients with coronary artery disease who presented to Farshchian Heart University Hospital, Hamadan, Iran. MATERIALS AND METHODS: In this descriptive cross-sectional study, we investigated some of the major atherosclerotic risk factors and their relationships with the type of coronary artery disease in terms of number and location of disease. A total of 1100 patients were enrolled with coronary artery disease confirmed by selective coronary angiography from 2010-2014. A p-value<0.05 was considered statistically significant. RESULTS: A total of 1100 patients enrolled in this study. The patient population consisted of 743 (67.5%) males and 357 (32.5%) females. A meaningful relationship existed between ageing, diabetes mellitus, hypertension and 3-Vessel Disease (3VD, p<0.001) as well as between hyperlipidemia and Single Vessel Disease (SVD, p<0.001). Patients diagnosed with diabetes mellitus, hypertension, and hyperlipidemia showed greater potential to develop coronary artery disease at the proximal section of the coronary arteries. CONCLUSION: Based on the relationship between some of the major risk factors and the pattern of coronary artery disease in the current study, prospective studies should investigate other risk factors. We recommend that a plan should be developed to reduce adjustable risk factors such as diabetes mellitus, hypertension and hyperlipidemia in order to decrease coronary artery disease.
Authors: Sidney C Smith; Amy Collins; Roberto Ferrari; David R Holmes; Susanne Logstrup; Diana Vaca McGhie; Johanna Ralston; Ralph L Sacco; Hans Stam; Kathryn Taubert; David A Wood; William A Zoghbi Journal: Eur Heart J Date: 2012-09-17 Impact factor: 29.983