Zainab Ahmed Ali-Eldin1, Fatma Ahmed Ali-Eldin2, Inas Elkhedr Mohamed1. 1. Assistant Professor, Department of Internal Medicine, Ain Shams University, Cairo, Egypt. 2. Assistant Professor, Department of Tropical Medicine, Ain Shams University, Cairo, Egypt.
Abstract
INTRODUCTION: Many clinical studies suggest a direct association between hepatic fat content and visceral adiposity and the progression of fibrosis. AIM: This work aims to clarify the relation between the Visceral Adiposity Index (VAI) and severity of necroinflammatory activity and liver fibrosis in Egyptian patients with chronic Hepatitis C Virus (HCV) infection. MATERIALS AND METHODS: A cross-sectional study, over a period of six months, was performed on 50 chronic HCV patients subjected to routine laboratory investigations, abdominal ultrasonography, measurement of Waist Circumference (WC), calculation of Body Mass Index (BMI) and VAI, ultrasound guided liver biopsy and assessment of hepatic fibrosis by METAVIR staging. RESULTS: A total of 50 HCV positive patients, 29 (58%) males and 21 (42%) females were included in the study. Age ranged from 29-60 years (44.4±8.4). BMI was ranged from 20.3 to 41.4 kg/m2 (31.7±5.5). VAI for males was 0.4±0.2 and for females was 0.5±0.3. There were significant positive correlations between VAI and BMI, Triglycerides (TG), fibrosis stages, grades of liver inflammation and FIB-4 Fibrosis-4 score. There were significant negative correlations between VAI and high density lipoprotein, platelets and haemoglobin. CONCLUSION: There is an association between visceral obesity represented by VAI and the severity of hepatic inflammatory response in chronic hepatitis C patients. Other studies are recommended to measure the clinical implication of visceral obesity on the response to the novel directly acting antivirals.
INTRODUCTION: Many clinical studies suggest a direct association between hepatic fat content and visceral adiposity and the progression of fibrosis. AIM: This work aims to clarify the relation between the Visceral Adiposity Index (VAI) and severity of necroinflammatory activity and liver fibrosis in Egyptian patients with chronic Hepatitis C Virus (HCV) infection. MATERIALS AND METHODS: A cross-sectional study, over a period of six months, was performed on 50 chronic HCVpatients subjected to routine laboratory investigations, abdominal ultrasonography, measurement of Waist Circumference (WC), calculation of Body Mass Index (BMI) and VAI, ultrasound guided liver biopsy and assessment of hepatic fibrosis by METAVIR staging. RESULTS: A total of 50 HCV positive patients, 29 (58%) males and 21 (42%) females were included in the study. Age ranged from 29-60 years (44.4±8.4). BMI was ranged from 20.3 to 41.4 kg/m2 (31.7±5.5). VAI for males was 0.4±0.2 and for females was 0.5±0.3. There were significant positive correlations between VAI and BMI, Triglycerides (TG), fibrosis stages, grades of liver inflammation and FIB-4 Fibrosis-4 score. There were significant negative correlations between VAI and high density lipoprotein, platelets and haemoglobin. CONCLUSION: There is an association between visceral obesity represented by VAI and the severity of hepatic inflammatory response in chronic hepatitis Cpatients. Other studies are recommended to measure the clinical implication of visceral obesity on the response to the novel directly acting antivirals.
Authors: Richard K Sterling; Eduardo Lissen; Nathan Clumeck; Ricard Sola; Mendes Cassia Correa; Julio Montaner; Mark S Sulkowski; Francesca J Torriani; Doug T Dieterich; David L Thomas; Diethelm Messinger; Mark Nelson Journal: Hepatology Date: 2006-06 Impact factor: 17.425
Authors: Calogero Cammà; Danilo Di Bona; Filippo Schepis; E Jenny Heathcote; Stefan Zeuzem; Paul J Pockros; Patrick Marcellin; Luis Balart; Alfredo Alberti; Antonio Craxì Journal: Hepatology Date: 2004-02 Impact factor: 17.425
Authors: Heather M Patton; Keyur Patel; Cynthia Behling; David Bylund; Lawrence M Blatt; Marc Vallée; Shanon Heaton; Andrew Conrad; Paul J Pockros; John G McHutchison Journal: J Hepatol Date: 2004-03 Impact factor: 25.083