Literature DB >> 28967956

Variability and Error in Cardiac Troponin Testing: An ACLPS Critical Review.

Daniel S Herman1, Peter A Kavsak2, Dina N Greene3.   

Abstract

OBJECTIVES: To provide a comprehensive overview of the complexities associated with cardiac troponin (cTn) testing. An emphasis is placed on the sources of error, organized into the preanalytical, analytical, and postanalytical phases of the testing pathway. Controversial areas are also explored.
METHODS: A case scenario and review of the relevant literature describing laboratory considerations involving cTn testing are described.
RESULTS: Advanced comprehension of the specific assay used in a given laboratory is necessary for optimal reporting, utilization, and quality monitoring of cTn.
CONCLUSIONS: cTn assays are reliable diagnostic tests for acute myocardial infarction, but understanding their limitations is required for appropriate result interpretation. © American Society for Clinical Pathology, 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Entities:  

Keywords:  Analytical sensitivity; Cardiac troponin; Error; False negative; False positive; Preanalytical; cTnI; cTnT

Mesh：

Substances：

Year:  2017        PMID： 28967956     DOI： 10.1093/ajcp/aqx066

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


  14 in total

1.  Reader comments.

Authors:  Paul G Pin; Sora Yasri; Viroj Wiwanitkit; Jeffrey Michel
Journal:  Proc (Bayl Univ Med Cent)       Date:  2018-12-18

Review 2.  Revisiting the Biological Variability of Cardiac Troponin: Implications for Clinical Practice.

Authors:  Nick S R Lan; Damon A Bell
Journal:  Clin Biochem Rev       Date:  2019-11

3.  Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department.

Authors:  Peter A Kavsak; Johannes T Neumann; Louise Cullen; Martin Than; Colleen Shortt; Jaimi H Greenslade; John W Pickering; Francisco Ojeda; Jinhui Ma; Natasha Clayton; Jonathan Sherbino; Stephen A Hill; Matthew McQueen; Dirk Westermann; Nils A Sörensen; William A Parsonage; Lauren Griffith; Shamir R Mehta; P J Devereaux; Mark Richards; Richard Troughton; Chris Pemberton; Sally Aldous; Stefan Blankenberg; Andrew Worster
Journal:  CMAJ       Date:  2018-08-20       Impact factor: 8.262

4.  Gradient-Based Rapid Digital Immunoassay for High-Sensitivity Cardiac Troponin T (hs-cTnT) Detection in 1 μL Plasma.

Authors:  Wenwen Jing; Yi Wang; Chao Chen; Fenni Zhang; Yunze Yang; Guangzhong Ma; Eric H Yang; Christine L N Snozek; Nongjian Tao; Shaopeng Wang
Journal:  ACS Sens       Date:  2020-10-09       Impact factor: 7.711

5.  Effect of type of diet on blood and plasma taurine concentrations, cardiac biomarkers, and echocardiograms in 4 dog breeds.

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Journal:  J Vet Intern Med       Date:  2021-02-27       Impact factor: 3.333

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Authors:  Andrea Saracevic; Lora Dukic; Ana-Maria Simundic
Journal:  Biochem Med (Zagreb)       Date:  2019-04-15       Impact factor: 2.313

7.  Prognostic implications of statin intolerance in stable coronary artery disease patients with different levels of high-sensitive troponin.

Authors:  Jo-Jo Hai; Yuen-Kwun Wong; Chun-Ka Wong; Ka-Chun Un; Pak-Hei Chan; Chung-Wah Siu; Kai-Hang Yiu; Chu-Pak Lau; Hung-Fat Tse
Journal:  BMC Cardiovasc Disord       Date:  2019-07-15       Impact factor: 2.298

8.  Turkish Society of Cardiology consensus paper on the rational use of cardiac troponins in daily practice.

Authors:  Kaan Okyay; Beste Özben Sadıç; Asife Şahinarslan; Murtaza Emre Durakoğlugil; Can Yücel Karabay; Semiha Emel Eryüksel; Özlem Gülbahar; Abdullah Tekin; Aylin Yıldırır; Bülent Görenek; Oğuz Yavuzgil; Ali Serdar Fak
Journal:  Anatol J Cardiol       Date:  2019-04-19       Impact factor: 1.596

Review 9.  Nanoscale Technologies for Prevention and Treatment of Heart Failure: Challenges and Opportunities.

Authors:  Mohammad Javad Hajipour; Mehdi Mehrani; Seyed Hesameddin Abbasi; Ahmad Amin; Seyed Ebrahim Kassaian; Jessica C Garbern; Giulio Caracciolo; Steven Zanganeh; Mitra Chitsazan; Haniyeh Aghaverdi; Seyed Mehdi Kamali Shahri; Aliakbar Ashkarran; Mohammad Raoufi; Holly Bauser-Heaton; Jianyi Zhang; Jochen D Muehlschlegel; Anna Moore; Richard T Lee; Joseph C Wu; Vahid Serpooshan; Morteza Mahmoudi
Journal:  Chem Rev       Date:  2019-09-06       Impact factor: 60.622

10.  Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum.

Authors:  Timothy N Tiambeng; David S Roberts; Kyle A Brown; Yanlong Zhu; Bifan Chen; Zhijie Wu; Stanford D Mitchell; Tania M Guardado-Alvarez; Song Jin; Ying Ge
Journal:  Nat Commun       Date:  2020-08-06       Impact factor: 14.919
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