Jitendra K S Parihar1, Jaya Kaushik2, Vaibhav K Jain3, Hemant S Trehan4, Avinash Mishra5, Vinod K Baranwal6. 1. 1 Department of Ophthalmology, Army Hospital Research and Referral, New Delhi - India. 2. 2 Department of Ophthalmology, Command Hospital (Western Command) and PG Medical Institute, Chandimandir Panchkula, Haryana - India. 3. 3 Department of Ophthalmology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow - India. 4. 4 Department of Ophthalmology, INHS Asvini and PG Medical Institute, Kolaba, Mumbai, Maharashtra - India. 5. 5 Department of Ophthalmology, Command Hospital (Eastern Command) and PG Medical Institute, Kolkata, West Bengal - India. 6. 6 Department of Ophthalmology, Base Hospital Delhi Cantt and Army College of Medical Sciences, New Delhi - India.
Abstract
PURPOSE: To evaluate the outcome of combined Ahmed glaucoma valve (AGV) and phacoemulsification with posterior chamber intraocular lens implantation under infliximab in refractory uveitic glaucoma (UG). METHODS: In this prospective interventional case series, 26 eyes of 26 patients with refractory UG underwent surgery under intravenous infliximab. The success rate was defined as intraocular pressure (IOP) 5 to 21 mm Hg with or without antiglaucoma medications (AGM), without additional glaucoma surgical intervention. RESULTS: The mean IOP (37.8 ± 11.86 to 12.2 ± 2.8 mm Hg; p<0.0001) and mean number of AGM (3.4 ± 1.2 to 0.4 ± 0.1; p<0.001) were significantly reduced after surgery at 2 years. Kaplan-Meier survival analysis showed a cumulative probability of success for IOP control of 92% at 2 years of follow-up. CONCLUSIONS: Combined AGV and phacoemulsification is an effective treatment for controlling refractory UG with complicated cataract under infliximab.
PURPOSE: To evaluate the outcome of combined Ahmed glaucoma valve (AGV) and phacoemulsification with posterior chamber intraocular lens implantation under infliximab in refractory uveitic glaucoma (UG). METHODS: In this prospective interventional case series, 26 eyes of 26 patients with refractory UG underwent surgery under intravenous infliximab. The success rate was defined as intraocular pressure (IOP) 5 to 21 mm Hg with or without antiglaucoma medications (AGM), without additional glaucoma surgical intervention. RESULTS: The mean IOP (37.8 ± 11.86 to 12.2 ± 2.8 mm Hg; p<0.0001) and mean number of AGM (3.4 ± 1.2 to 0.4 ± 0.1; p<0.001) were significantly reduced after surgery at 2 years. Kaplan-Meier survival analysis showed a cumulative probability of success for IOP control of 92% at 2 years of follow-up. CONCLUSIONS: Combined AGV and phacoemulsification is an effective treatment for controlling refractory UG with complicated cataract under infliximab.
Entities:
Keywords:
Ahmed glaucoma valve; Behçet disease; Infliximab; Postuveitic cataract and glaucoma; Uveitic glaucoma; Uveitis
Authors: Lin Fu; Yau Kei Chan; Li Nie; Qi Dai; Zhenbin Qian; Kendrick Co Shih; Jimmy Shiu Ming Lai; Rong Huang; Weihua Pan Journal: BMC Ophthalmol Date: 2019-02-06 Impact factor: 2.209