Literature DB >> 28966969

Utilizing a unique animal model to better understand human temperament.

Cortney A Turner1, Shelly B Flagel1,2, Peter Blandino1, Stanley J Watson1,2, Huda Akil1,2.   

Abstract

Individual differences in temperament are associated with psychopathology in humans. Moreover, the relationship between temperament and anxiety-, depression-, PTSD- and addiction-related behaviors can be modeled in animals. This review will highlight these relationships with a focus on individual differences in the response to stressors, fear conditioning and drugs of abuse using animals that differ in their response to a novel environment. We will discuss behavioral and neurobiological commonalities amongst these behaviors with a focus on the hippocampus and, in particular, growth factors as promising novel targets for therapeutic intervention.

Entities:  

Keywords:  PTSD; addiction; anxiety; depression

Year:  2017        PMID： 28966969      PMCID： PMC5616177          DOI： 10.1016/j.cobeha.2017.02.002

Source DB:  PubMed          Journal:  Curr Opin Behav Sci        ISSN： 2352-1546


  57 in total

1.  Emotional traits predict individual differences in amphetamine-induced positive mood in healthy volunteers.

Authors:  Matthew G Kirkpatrick; Nicholas I Goldenson; Nahel Kapadia; Christopher W Kahler; Harriet de Wit; Robert M Swift; John E McGeary; Steve Sussman; Adam M Leventhal
Journal:  Psychopharmacology (Berl)       Date:  2015-10-02       Impact factor: 4.530

2.  Corticosterone combined with intramedial prefrontal cortex infusion of SCH 23390 impairs the strong fear response in high-fear-reactivity rats.

Authors:  Xian-Li An; Xi-Geng Zheng; Jing Liang; Yun-Jing Bai
Journal:  Psych J       Date:  2012-08-12

3.  Memory consolidation of fear conditioning: bi-stable amygdala connectivity with dorsal anterior cingulate and medial prefrontal cortex.

Authors:  Pan Feng; Tingyong Feng; Zhencai Chen; Xu Lei
Journal:  Soc Cogn Affect Neurosci       Date:  2013-11-04       Impact factor: 3.436

4.  Antagonism of κ opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence.

Authors:  Gui-Ying Zan; Qian Wang; Yu-Jun Wang; Yao Liu; Ai Hang; Xiao-Hong Shu; Jing-Gen Liu
Journal:  Behav Brain Res       Date:  2015-06-03       Impact factor: 3.332

5.  Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats.

Authors:  M E Glover; P C Pugh; N L Jackson; J L Cohen; A D Fant; H Akil; S M Clinton
Journal:  Neuroscience       Date:  2014-11-04       Impact factor: 3.590

6.  Individual differences in the forced swimming test and the effect of environmental enrichment: searching for an interaction.

Authors:  A Sequeira-Cordero; A Mora-Gallegos; P Cuenca-Berger; J Fornaguera-Trías
Journal:  Neuroscience       Date:  2014-02-05       Impact factor: 3.590

7.  HPA axis genetic variation, pubertal status, and sex interact to predict amygdala and hippocampus responses to negative emotional faces in school-age children.

Authors:  David Pagliaccio; Joan L Luby; Ryan Bogdan; Arpana Agrawal; Michael S Gaffrey; Andrew C Belden; Kelly N Botteron; Michael P Harms; Deanna M Barch
Journal:  Neuroimage       Date:  2015-01-09       Impact factor: 6.556

8.  Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes.

Authors:  Nikolaos P Daskalakis; Hagit Cohen; Guiqing Cai; Joseph D Buxbaum; Rachel Yehuda
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-11       Impact factor: 11.205

9.  Fibroblast Growth Factor 2 Sits at the Interface of Stress and Anxiety.

Authors:  Cortney A Turner; Stanley J Watson; Huda Akil
Journal:  Biol Psychiatry       Date:  2016-09-15       Impact factor: 13.382

10.  Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine.

Authors:  Florian Duclot; Iara Perez-Taboada; Katherine N Wright; Mohamed Kabbaj
Journal:  Neuropharmacology       Date:  2016-06-22       Impact factor: 5.250
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  3 in total

1.  Genetic Liability for Internalizing Versus Externalizing Behavior Manifests in the Developing and Adult Hippocampus: Insight From a Meta-analysis of Transcriptional Profiling Studies in a Selectively Bred Rat Model.

Authors:  Isabelle A Birt; Megan H Hagenauer; Sarah M Clinton; Cigdem Aydin; Peter Blandino; John D H Stead; Kathryn L Hilde; Fan Meng; Robert C Thompson; Huzefa Khalil; Alex Stefanov; Pamela Maras; Zhifeng Zhou; Elaine K Hebda-Bauer; David Goldman; Stanley J Watson; Huda Akil
Journal:  Biol Psychiatry       Date:  2020-05-27       Impact factor: 13.382

2.  Inborn differences in emotional behavior coincide with alterations in hypothalamic paraventricular motor projections.

Authors:  Elizabeth A Shupe; Matthew E Glover; Keaton A Unroe; Ilan A Kerman; Sarah M Clinton
Journal:  Eur J Neurosci       Date:  2020-12-15       Impact factor: 3.386

3.  Behavioral Management as a Coping Strategy for Managing Stressors in Primates: The Influence of Temperament and Species.

Authors:  Sierra Palmer; Scott Hunter Oppler; Melanie L Graham
Journal:  Biology (Basel)       Date:  2022-03-10
  3 in total

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