Literature DB >> 28966788

Identification of a Fragmented Small GTPase Capable of Conditional Effector Binding.

Jia Zhao1, Cliff I Stains1.   

Abstract

A fragmented small GTPase capable of conditional effector binding is described. The effector binding function of this split-GTPase can be modulated using a small molecule input, thus allowing for the potential design of cellular signaling pathways.

Entities:  

Year:  2017        PMID： 28966788      PMCID： PMC5619660          DOI： 10.1039/C6RA25575B

Source DB:  PubMed          Journal:  RSC Adv        ISSN： 2046-2069            Impact factor:   3.361


  39 in total

1.  Structure of Cdc42 bound to the GTPase binding domain of PAK.

Authors:  A Morreale; M Venkatesan; H R Mott; D Owen; D Nietlispach; P N Lowe; E D Laue
Journal:  Nat Struct Biol       Date:  2000-05

Review 2.  Exploring protein interactions by interaction-induced folding of proteins from complementary peptide fragments.

Authors:  S W Michnick
Journal:  Curr Opin Struct Biol       Date:  2001-08       Impact factor: 6.809

3.  Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods.

Authors:  Valerie Benard; Gary M Bokoch
Journal:  Methods Enzymol       Date:  2002       Impact factor: 1.600

Review 4.  Protein translocation as a tool: The current rapamycin story.

Authors:  Mateusz Putyrski; Carsten Schultz
Journal:  FEBS Lett       Date:  2012-05-11       Impact factor: 4.124

5.  Delineation of the Cdc42/Rac-binding domain of p21-activated kinase.

Authors:  G Thompson; D Owen; P A Chalk; P N Lowe
Journal:  Biochemistry       Date:  1998-05-26       Impact factor: 3.162

Review 6.  Drugging the undruggable RAS: Mission possible?

Authors:  Adrienne D Cox; Stephen W Fesik; Alec C Kimmelman; Ji Luo; Channing J Der
Journal:  Nat Rev Drug Discov       Date:  2014-10-17       Impact factor: 84.694

7.  Localized Rac activation dynamics visualized in living cells.

Authors:  V S Kraynov; C Chamberlain; G M Bokoch; M A Schwartz; S Slabaugh; K M Hahn
Journal:  Science       Date:  2000-10-13       Impact factor: 47.728

8.  Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

Authors:  J Chen; X F Zheng; E J Brown; S L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-23       Impact factor: 11.205

Review 9.  The Ras protein superfamily: evolutionary tree and role of conserved amino acids.

Authors:  Ana Maria Rojas; Gloria Fuentes; Antonio Rausell; Alfonso Valencia
Journal:  J Cell Biol       Date:  2012-01-23       Impact factor: 10.539

10.  A genetically encoded photoactivatable Rac controls the motility of living cells.

Authors:  Yi I Wu; Daniel Frey; Oana I Lungu; Angelika Jaehrig; Ilme Schlichting; Brian Kuhlman; Klaus M Hahn
Journal:  Nature       Date:  2009-08-19       Impact factor: 49.962
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  1 in total

1.  An Evolutionary Strategy for Identification of Higher Order, Green Fluorescent Host-Guest Pairs Compatible with Living Systems.

Authors:  Garrett R Casey; Xinqi Zhou; Lauren Lesiak; Bi Xu; Yuan Fang; Donald F Becker; Cliff I Stains
Journal:  Chemistry       Date:  2020-11-09       Impact factor: 5.236
  1 in total

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