Literature DB >> 2896632

Tightly linked markers for the neurofibromatosis type 1 gene.

R White1, Y Nakamura, P O'Connell, M Leppert, J M Lalouel, D Barker, D Goldgar, M Skolnick, J Carey, C E Wallis.   

Abstract

Relationships among genetic markers in the region of the neurofibromatosis type 1 (NF1) gene on chromosome 17 were investigated by linkage studies in a large sample set of affected families and in a panel of 58 normal families. A new marker, pHHH202 (D17S33), was included along with two markers known to be closely linked to NF. The maximum likelihood estimate of the recombination rate between the pHHH202 and NF1 loci was found to be O. Multilocus analysis suggested the following marker order: pA10-41-(p3-6, pHHH202); the NF1 gene fell with equal likelihood between either pA10-41-p3-6 or p3-6-pHHH202. The odds against NF1 being outside this cluster of tightly linked markers were greater than 15:1.

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Year:  1987        PMID： 2896632     DOI： 10.1016/0888-7543(87)90040-1

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  19 in total

1.  Molecular study in von Recklinghausen neurofibromatosis (NF1).

Authors:  R Vivarelli; G Bartalini; L Calistri; P Balestri; A Figus; M Pirastu; A Cao; A Fois
Journal:  Childs Nerv Syst       Date:  1991-04       Impact factor: 1.475

2.  Refined physical and genetic mapping of the NF1 region on chromosome 17.

Authors:  P R Fain; D E Goldgar; M R Wallace; F S Collins; E Wright; K Nguyen; D F Barker
Journal:  Am J Hum Genet       Date:  1989-11       Impact factor: 11.025

3.  Flanking markers for the gene causing von Recklinghausen neurofibromatosis (NF1).

Authors:  B R Seizinger; G E Farmer; J L Haines; L J Ozelius; K Anderson; B R Korf; D M Parry; M A Pericak-Vance; J J Mulvihill; A Menon
Journal:  Am J Hum Genet       Date:  1989-01       Impact factor: 11.025

4.  Linkage analysis of neurofibromatosis type 1. Study of a homogeneous North Italian population with five DNA markers of chromosome 17.

Authors:  M Clementi; A Murgia; F Anglani; R Tenconi; L Turolla; L Picci; F Zacchello
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

5.  The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin.

Authors:  G R Skuse; B A Kosciolek; P T Rowley
Journal:  Am J Hum Genet       Date:  1991-09       Impact factor: 11.025

6.  Large de novo DNA deletion in a patient with sporadic neurofibromatosis 1, mental retardation, and dysmorphism.

Authors:  L M Kayes; V M Riccardi; W Burke; R L Bennett; K Stephens
Journal:  J Med Genet       Date:  1992-10       Impact factor: 6.318

7.  Genetics of neurofibromatosis 1 in Japan: mutation rate and paternal age effect.

Authors:  T Takano; T Kawashima; Y Yamanouchi; K Kitayama; T Baba; K Ueno; H Hamaguchi
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132

Review 8.  Molecular genetics of neurofibromatosis type 1 (NF1).

Authors:  M H Shen; P S Harper; M Upadhyaya
Journal:  J Med Genet       Date:  1996-01       Impact factor: 6.318

9.  Preferential mutation of the neurofibromatosis type 1 gene in paternally derived chromosomes.

Authors:  K Stephens; L Kayes; V M Riccardi; M Rising; V P Sybert; R A Pagon
Journal:  Hum Genet       Date:  1992-01       Impact factor: 4.132

10.  A refined genetic map of the region of chromosome 17 surrounding the von Recklinghausen neurofibromatosis (NF1) gene.

Authors:  S R Diehl; M Boehnke; R P Erickson; L M Ploughman; K A Seiler; J L Lieberman; H B Clarke; M A Bruce; E K Schorry; M Pericak-Vance
Journal:  Am J Hum Genet       Date:  1989-01       Impact factor: 11.025
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