Pernille Hededal1,2, Mikkel Østergaard1,2, Inge Juul Sørensen1,2, Anne Gitte Loft1,2, Jens S Hindrup1,2, Gorm Thamsborg1,2, Karsten Asmussen1,2, Oliver Hendricks1,2, Jesper Nørregaard1,2, Jakob M Møller1,2, Anne Grethe Jurik1,2, Lone Morsel1,2, Lone Balding1,2, Susanne Juhl Pedersen3,4. 1. From the Department of Radiology, and the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, University of Copenhagen, Glostrup; Department of Clinical Medicine, Faculty of Health Sciences, and the Center for Rheumatology and Spine Diseases, Gentofte Hospital, and the Center for Rheumatology and Spine Diseases, Bispebjerg and Frederiksberg Hospital, and the Center for Rheumatology and Spine Diseases, Nordsjællands Hospital, and the Department of Radiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen; Department of Rheumatology, Sygehus Lillebaelt, Vejle; King Christian 10th Rheumatism Hospital, Graasten; Department of Radiology, and Department of Rheumatology, Aarhus University Hospital, Denmark. 2. P. Hededal, MD, Department of Radiology, Rigshospitalet, University of Copenhagen; M. Østergaard, Professor, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen; I.J. Sørensen, PhD, Consultant, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen; A.G. Loft, DMSc, consultant, Department of Rheumatology, Sygehus Lillebaelt, and Department of Rheumatology, Aarhus University Hospital; J.S. Hindrup, PhD, consultant, Center for Rheumatology and Spine Diseases, Gentofte Hospital, University of Copenhagen; G. Thamsborg, DMSc, consultant, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, University of Copenhagen; K. Asmussen, PhD, consultant, Center for Rheumatology and Spine Diseases, Bispebjerg and Frederiksberg Hospital, University of Copenhagen; O. Hendricks, PhD, consultant, King Christian 10th Rheumatism Hospital; J. Nørregaard, DMSc, consultant, Center for Rheumatology and Spine Diseases, Nordsjællands Hospital, University of Copenhagen; J.M. Møller, MSc, research radiographer, Department of Radiology, Herlev and Gentofte Hospital, University of Copenhagen; A.G. Jurik, DMSc, Professor, Department of Radiology, Aarhus University Hospital; L. Morsel, consultant, Department of Radiology, Rigshospitalet, University of Copenhagen; L. Balding, consultant, Department of Radiology, Herlev and Gentofte Hospital, University of Copenhagen; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, University of Copenhagen. 3. From the Department of Radiology, and the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, University of Copenhagen, Glostrup; Department of Clinical Medicine, Faculty of Health Sciences, and the Center for Rheumatology and Spine Diseases, Gentofte Hospital, and the Center for Rheumatology and Spine Diseases, Bispebjerg and Frederiksberg Hospital, and the Center for Rheumatology and Spine Diseases, Nordsjællands Hospital, and the Department of Radiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen; Department of Rheumatology, Sygehus Lillebaelt, Vejle; King Christian 10th Rheumatism Hospital, Graasten; Department of Radiology, and Department of Rheumatology, Aarhus University Hospital, Denmark. susanne_juhl_ped@dadlnet.dk. 4. P. Hededal, MD, Department of Radiology, Rigshospitalet, University of Copenhagen; M. Østergaard, Professor, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen; I.J. Sørensen, PhD, Consultant, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen; A.G. Loft, DMSc, consultant, Department of Rheumatology, Sygehus Lillebaelt, and Department of Rheumatology, Aarhus University Hospital; J.S. Hindrup, PhD, consultant, Center for Rheumatology and Spine Diseases, Gentofte Hospital, University of Copenhagen; G. Thamsborg, DMSc, consultant, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, University of Copenhagen; K. Asmussen, PhD, consultant, Center for Rheumatology and Spine Diseases, Bispebjerg and Frederiksberg Hospital, University of Copenhagen; O. Hendricks, PhD, consultant, King Christian 10th Rheumatism Hospital; J. Nørregaard, DMSc, consultant, Center for Rheumatology and Spine Diseases, Nordsjællands Hospital, University of Copenhagen; J.M. Møller, MSc, research radiographer, Department of Radiology, Herlev and Gentofte Hospital, University of Copenhagen; A.G. Jurik, DMSc, Professor, Department of Radiology, Aarhus University Hospital; L. Morsel, consultant, Department of Radiology, Rigshospitalet, University of Copenhagen; L. Balding, consultant, Department of Radiology, Herlev and Gentofte Hospital, University of Copenhagen; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, University of Copenhagen. susanne_juhl_ped@dadlnet.dk.
Abstract
OBJECTIVE: To develop semiaxial magnetic resonance imaging (MRI) scoring methods for assessment of sacroiliac joint (SIJ) bone marrow edema (BME) in patients with axial spondyloarthritis, and to compare the reliability with equivalent semicoronal scoring methods. METHODS: Two semiaxial SIJ MRI scoring methods were developed based on the principles of the semicoronal Berlin and Spondyloarthritis Research Consortium of Canada (SPARCC) methods. A global quadrant-based method was also developed. Baseline and 12-week MRI of the SIJ from 51 patients participating in a randomized double-blind placebo-controlled trial of adalimumab 40 mg every other week versus placebo were scored by the semiaxial and the corresponding semicoronal methods. Results were compared by linear regression analysis. The reproducibility and sensitivity were evaluated by intraclass correlation coefficients (ICC) and smallest detectable change [SDC, absolute values and percentage of the highest observed score (SDC-HOS)]. RESULTS: Interreader and intrareader ICC were moderate to very high for semiaxial scoring methods (baseline 0.83-0.88 and 0.85-0.97; change 0.33-0.78), while high to very high for semicoronal scoring methods (baseline 0.90-0.92 and 0.93-0.97; change 0.77-0.89). Association between semiaxial and semicoronal scores were high for both the Berlin and SPARCC method (baseline: R2 = 0.93 and 0.88; change: R2 = 0.82 and 0.87, respectively), while lower for the global method (baseline: R2 = 0.79; change: R2 = 0.54). The SDC-HOS were 9.8-18.6% and 5.9-10.7% for the semiaxial and semicoronal methods, respectively. CONCLUSION: Detection of SIJ BME in the semiaxial scan plane is feasible and reproducible. However, a slightly lower reliability of all 3 semiaxial methods supports the general practice of using the coronal scan-plane in therapeutic studies.
RCT Entities:
OBJECTIVE: To develop semiaxial magnetic resonance imaging (MRI) scoring methods for assessment of sacroiliac joint (SIJ) bone marrow edema (BME) in patients with axial spondyloarthritis, and to compare the reliability with equivalent semicoronal scoring methods. METHODS: Two semiaxial SIJ MRI scoring methods were developed based on the principles of the semicoronal Berlin and Spondyloarthritis Research Consortium of Canada (SPARCC) methods. A global quadrant-based method was also developed. Baseline and 12-week MRI of the SIJ from 51 patients participating in a randomized double-blind placebo-controlled trial of adalimumab 40 mg every other week versus placebo were scored by the semiaxial and the corresponding semicoronal methods. Results were compared by linear regression analysis. The reproducibility and sensitivity were evaluated by intraclass correlation coefficients (ICC) and smallest detectable change [SDC, absolute values and percentage of the highest observed score (SDC-HOS)]. RESULTS: Interreader and intrareader ICC were moderate to very high for semiaxial scoring methods (baseline 0.83-0.88 and 0.85-0.97; change 0.33-0.78), while high to very high for semicoronal scoring methods (baseline 0.90-0.92 and 0.93-0.97; change 0.77-0.89). Association between semiaxial and semicoronal scores were high for both the Berlin and SPARCC method (baseline: R2 = 0.93 and 0.88; change: R2 = 0.82 and 0.87, respectively), while lower for the global method (baseline: R2 = 0.79; change: R2 = 0.54). The SDC-HOS were 9.8-18.6% and 5.9-10.7% for the semiaxial and semicoronal methods, respectively. CONCLUSION: Detection of SIJ BME in the semiaxial scan plane is feasible and reproducible. However, a slightly lower reliability of all 3 semiaxial methods supports the general practice of using the coronal scan-plane in therapeutic studies.
Entities:
Keywords:
BONE MARROW EDEMA; MAGNETIC RESONANCE IMAGING; SACROILIAC JOINT; SEMIAXIAL SCORING; SEMICORONAL SCORING
Authors: Florence W L Tsui; Aifeng Lin; Ismail Sari; Zhenbo Zhang; Hing Wo Tsui; Robert D Inman Journal: Arthritis Res Ther Date: 2021-05-14 Impact factor: 5.156
Authors: Florence W L Tsui; Aifeng Lin; Ismail Sari; Zhenbo Zhang; Kenneth P H Pritzker; Hing Wo Tsui; Robert D Inman Journal: Arthritis Res Ther Date: 2022-07-08 Impact factor: 5.606