Literature DB >> 2896605

Intramitochondrial factors controlling hepatic fatty acid oxidation at weaning in the rat.

J F Decaux1, D Robin, P Robin, P Ferré, J Girard.   

Abstract

Fatty acid oxidation was studied in isolated liver mitochondria of rats during the suckling-weaning transition. The oxidation rate of oleyl-CoA and palmitoylcarnitine was reduced 2.5-fold in rats weaned on a high-carbohydrate diet compared to suckling rats, when acetyl-CoA produced by beta-oxidation was directed towards ketone-body synthesis. Weaning on a high-fat diet minimized this change. Channeling of acetyl-CoA towards citrate synthesis doubled the oxidation rate of both substrates in HC-weaned rats. Thus, in addition to changes in carnitine palmitoyltransferase I activity, the beta-hydroxymethylglutaryl-CoA synthase pathway is also involved in the decreased fatty acid oxidation at weaning. This was confirmed by measurement of beta-hydroxymethylglutaryl-CoA synthase pathway activity.

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Year:  1988        PMID： 2896605     DOI： 10.1016/0014-5793(88)80407-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis.

Authors:  N Casals; N Roca; M Guerrero; G Gil-Gómez; J Ayté; C J Ciudad; F G Hegardt
Journal:  Biochem J       Date:  1992-04-01       Impact factor: 3.857

Review 2.  Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis.

Authors:  F G Hegardt
Journal:  Biochem J       Date:  1999-03-15       Impact factor: 3.857

3.  Treatment of rats with glucagon or mannoheptulose increases mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase activity and decreases succinyl-CoA content in liver.

Authors:  P A Quant; P K Tubbs; M D Brand
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

4.  Gene expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in a poorly ketogenic mammal: effect of starvation during the neonatal period of the piglet.

Authors:  S H Adams; C S Alho; G Asins; F G Hegardt; P F Marrero
Journal:  Biochem J       Date:  1997-05-15       Impact factor: 3.857

5.  Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.

Authors:  Yuichiro Arima; Yoshiko Nakagawa; Toru Takeo; Toshifumi Ishida; Toshihiro Yamada; Shinjiro Hino; Mitsuyoshi Nakao; Sanshiro Hanada; Terumasa Umemoto; Toshio Suda; Tetsushi Sakuma; Takashi Yamamoto; Takehisa Watanabe; Katsuya Nagaoka; Yasuhito Tanaka; Yumiko K Kawamura; Kazuo Tonami; Hiroki Kurihara; Yoshifumi Sato; Kazuya Yamagata; Taishi Nakamura; Satoshi Araki; Eiichiro Yamamoto; Yasuhiro Izumiya; Kenji Sakamoto; Koichi Kaikita; Kenichi Matsushita; Koichi Nishiyama; Naomi Nakagata; Kenichi Tsujita
Journal:  Nat Metab       Date:  2021-02-18

6.  Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats.

Authors:  A Valera; J E Rodriguez-Gil; F Bosch
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

7.  Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes.

Authors:  J Ayté; G Gil-Gómez; D Haro; P F Marrero; F G Hegardt
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205
  7 in total

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