Anne S Siegmund1, Marlies A M Kampman2, Caterina M Bilardo3, Ali Balci4, Arie P J van Dijk5, Martijn A Oudijk6, Barbara J M Mulder7, Jolien W Roos-Hesselink8, Gertjan Tj Sieswerda9, Steven V Koenen10, Krystyna M Sollie-Szarynska3, Tjark Ebels11, Dirk J van Veldhuisen1, Petronella G Pieper12. 1. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. 2. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; The Netherlands Heart Institute (ICIN), Utrecht, The Netherlands. 3. Department of Obstetrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. 4. Department of Cardiology, Isala, Zwolle, The Netherlands. 5. Department of Cardiology, Radboud University Medical Center, Radboud University, Nijmegen, The Netherlands. 6. Department of Obstetrics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 7. Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 8. Department of Cardiology, Erasmus Medical Center, University of Rotterdam, Rotterdam, The Netherlands. 9. Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands. 10. Department of Obstetrics, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands. 11. Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. 12. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: p.g.pieper@umcg.nl.
Abstract
OBJECTIVE: Women with repaired coarctation of the aorta (rCoA) are at risk of hypertensive disorders and other complications during pregnancy. Hypertensive disorders in pregnant women are associated with inadequate uteroplacental flow, which is related to adverse offspring outcome. The aim of this study was to investigate the relationship of maternal cardiac function, placental function and pregnancy complications in women with rCoA. METHODS: We included 49 pregnant women with rCoA and 69 controls from the prospective ZAHARA-studies (Zwangerschap bij Aangeboren HARtAfwijkingen, pregnancy in congenital heart disease). Clinical evaluation, echocardiography and uteroplacental Doppler flow (UDF) measurements were performed at 20 and 32weeks gestation. Univariable regression analysis was performed. RESULTS: Comparison of rCoA and healthy women. In women with rCoA, tricuspid annular plane systolic excursion (TAPSE) decreased during pregnancy (25.7mm to 22.8mm, P=0.006). UDF indices and pregnancy complication rates were similar in both groups. Offspring of rCoA women had lower birth weight (3233g versus 3578g, P=0.001), which was associated with β-blocker use during pregnancy (β=-418.0, P=0.01). Association of cardiac function and UDF. Right ventricular (RV) function before pregnancy (TAPSE) and at 20weeks gestation (TAPSE and RV fractional area change) were associated with impaired UDF indices (umbilical artery pulsatility index at 20weeks β=-0.02, P=0.01, resistance index at 20 and 32weeks β=-0.01, P=0.02 and β=-0.02, P=0.01 and uterine artery pulsatility and resistance index at 20weeks gestation β=-0.02, P=0.05 and β=-0.01, P=0.02). CONCLUSIONS: Women with rCoA tolerate pregnancy well. However, RV function is altered and is associated with impaired placentation.
OBJECTIVE:Women with repaired coarctation of the aorta (rCoA) are at risk of hypertensive disorders and other complications during pregnancy. Hypertensive disorders in pregnant women are associated with inadequate uteroplacental flow, which is related to adverse offspring outcome. The aim of this study was to investigate the relationship of maternal cardiac function, placental function and pregnancy complications in women with rCoA. METHODS: We included 49 pregnant women with rCoA and 69 controls from the prospective ZAHARA-studies (Zwangerschap bij Aangeboren HARtAfwijkingen, pregnancy in congenital heart disease). Clinical evaluation, echocardiography and uteroplacental Doppler flow (UDF) measurements were performed at 20 and 32weeks gestation. Univariable regression analysis was performed. RESULTS: Comparison of rCoA and healthy women. In women with rCoA, tricuspid annular plane systolic excursion (TAPSE) decreased during pregnancy (25.7mm to 22.8mm, P=0.006). UDF indices and pregnancy complication rates were similar in both groups. Offspring of rCoA women had lower birth weight (3233g versus 3578g, P=0.001), which was associated with β-blocker use during pregnancy (β=-418.0, P=0.01). Association of cardiac function and UDF. Right ventricular (RV) function before pregnancy (TAPSE) and at 20weeks gestation (TAPSE and RV fractional area change) were associated with impaired UDF indices (umbilical artery pulsatility index at 20weeks β=-0.02, P=0.01, resistance index at 20 and 32weeks β=-0.01, P=0.02 and β=-0.02, P=0.01 and uterine artery pulsatility and resistance index at 20weeks gestation β=-0.02, P=0.05 and β=-0.01, P=0.02). CONCLUSIONS:Women with rCoA tolerate pregnancy well. However, RV function is altered and is associated with impaired placentation.
Authors: Karishma P Ramlakhan; Daniel Tobler; Matthias Greutmann; Markus Schwerzmann; Lucia Baris; Anji T Yetman; Petros Nihoyannopoulos; Pravin Manga; Eric Boersma; Aldo P Maggioni; Mark R Johnson; Roger Hall; Jolien W Roos-Hesselink Journal: Heart Date: 2020-10-29 Impact factor: 5.994