Literature DB >> 28965973

MENIN loss as a tissue-specific driver of tumorigenesis.

Janet W Y Li1, Xianxin Hua2, Diane Reidy-Lagunes3, Brian R Untch4.   

Abstract

The MEN1 gene encodes MENIN, a tumor suppressor that plays a role in multiple cellular processes. Germline and somatic mutations in MEN1 have been identified in hereditary and sporadic tumors of neuroendocrine origins suggesting context-specific functions. In this review, we focus on the development of mutational Men1 in vivo models, the known cellular activities of MENIN and efforts to identify vulnerabilities in tumors with MENIN loss.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  MEN1; MENIN; Multiple endocrine neoplasia type 1; Pancreatic neuroendocrine tumor; Tumor suppressor gene

Mesh：

Substances：

Year:  2017        PMID： 28965973      PMCID： PMC8064664          DOI： 10.1016/j.mce.2017.09.032

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  64 in total

1.  Genetic aspects of adenomatosis of endocrine glands.

Authors:  P WERMER
Journal:  Am J Med       Date:  1954-03       Impact factor: 4.965

2.  A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.

Authors:  J S Crabtree; P C Scacheri; J M Ward; L Garrett-Beal; M R Emmert-Buck; K A Edgemon; D Lorang; S K Libutti; S C Chandrasekharappa; S J Marx; A M Spiegel; F S Collins
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-30       Impact factor: 11.205

3.  Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.

Authors:  Dmitry Borkin; Shihan He; Hongzhi Miao; Katarzyna Kempinska; Jonathan Pollock; Jennifer Chase; Trupta Purohit; Bhavna Malik; Ting Zhao; Jingya Wang; Bo Wen; Hongliang Zong; Morgan Jones; Gwenn Danet-Desnoyers; Monica L Guzman; Moshe Talpaz; Dale L Bixby; Duxin Sun; Jay L Hess; Andrew G Muntean; Ivan Maillard; Tomasz Cierpicki; Jolanta Grembecka
Journal:  Cancer Cell       Date:  2015-03-26       Impact factor: 31.743

4.  Wnt signaling regulates pancreatic beta cell proliferation.

Authors:  Ingrid C Rulifson; Satyajit K Karnik; Patrick W Heiser; Derk ten Berge; Hainan Chen; Xueying Gu; Makoto M Taketo; Roel Nusse; Matthias Hebrok; Seung K Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-02       Impact factor: 11.205

5.  DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.

Authors:  Yuchen Jiao; Chanjuan Shi; Barish H Edil; Roeland F de Wilde; David S Klimstra; Anirban Maitra; Richard D Schulick; Laura H Tang; Christopher L Wolfgang; Michael A Choti; Victor E Velculescu; Luis A Diaz; Bert Vogelstein; Kenneth W Kinzler; Ralph H Hruban; Nickolas Papadopoulos
Journal:  Science       Date:  2011-01-20       Impact factor: 47.728

6.  Somatic mutation of the MEN1 gene in parathyroid tumours.

Authors:  C Heppner; M B Kester; S K Agarwal; L V Debelenko; M R Emmert-Buck; S C Guru; P Manickam; S E Olufemi; M C Skarulis; J L Doppman; R H Alexander; Y S Kim; S K Saggar; I A Lubensky; Z Zhuang; L A Liotta; S C Chandrasekharappa; F S Collins; A M Spiegel; A L Burns; S J Marx
Journal:  Nat Genet       Date:  1997-08       Impact factor: 38.330

7.  Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.

Authors:  S K Agarwal; S C Guru; C Heppner; M R Erdos; R M Collins; S Y Park; S Saggar; S C Chandrasekharappa; F S Collins; A M Spiegel; S J Marx; A L Burns
Journal:  Cell       Date:  1999-01-08       Impact factor: 41.582

8.  Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.

Authors:  Philippe Bertolino; Ivan Radovanovic; Huguette Casse; Adriano Aguzzi; Zhao-Qi Wang; Chang-Xian Zhang
Journal:  Mech Dev       Date:  2003-05       Impact factor: 1.882

9.  Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter.

Authors:  Sunita K Agarwal; Elizabeth A Novotny; Judy S Crabtree; Jonathan B Weitzman; Moshe Yaniv; A Lee Burns; Settara C Chandrasekharappa; Francis S Collins; Allen M Spiegel; Stephen J Marx
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-05       Impact factor: 11.205

10.  Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma.

Authors:  C Larsson; B Skogseid; K Oberg; Y Nakamura; M Nordenskjöld
Journal:  Nature       Date:  1988-03-03       Impact factor: 49.962
View more
  7 in total

1.  Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription.

Authors:  Bryson W Katona; Rebecca A Glynn; Kayla E Paulosky; Zijie Feng; Caroline I Davis; Jian Ma; Corbett T Berry; Katherine M Szigety; Smita Matkar; Yuanyuan Liu; Haoren Wang; Yuan Wu; Xin He; Bruce D Freedman; Donita C Brady; Xianxin Hua
Journal:  Cancer Res       Date:  2019-03-15       Impact factor: 12.701

2.  A large Turkish pedigree with multiple endocrine neoplasia type 1 syndrome carrying a rare mutation: c.1680_1683 del TGAG.

Authors:  Coşkun Özer Demirtaş; Pınar Ata; Ali Çetin; Ayberk Türkyılmaz; Deniz Guney Duman
Journal:  Turk J Gastroenterol       Date:  2020-07       Impact factor: 1.852

3.  Menin: Expanding and dichotomous roles in cancer.

Authors:  Bryson W Katona; Rebecca A Glynn; Taylor A Hojnacki; Xianxin Hua
Journal:  Oncoscience       Date:  2019-08-23

4.  Multiple endocrine neoplasia type 1 combined with thyroid neoplasm: A case report and review of literatures.

Authors:  Jia-Lu Xu; Su Dong; Le-Le Sun; Jin-Xin Zhu; Jia Liu
Journal:  World J Clin Cases       Date:  2022-01-21       Impact factor: 1.337

5.  A Novel Isogenic Human Cell-Based System for MEN1 Syndrome Generated by CRISPR/Cas9 Genome Editing.

Authors:  Natalia Klementieva; Daria Goliusova; Julia Krupinova; Vladislav Yanvarev; Alexandra Panova; Natalia Mokrysheva; Sergey L Kiselev
Journal:  Int J Mol Sci       Date:  2021-11-08       Impact factor: 5.923

6.  Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer.

Authors:  Devi D Nelakurti; Amrit L Pappula; Swetha Rajasekaran; Wayne O Miles; Ruben C Petreaca
Journal:  Cancers (Basel)       Date:  2020-09-14       Impact factor: 6.639

7.  Menin-mediated Repression of Glycolysis in Combination with Autophagy Protects Colon Cancer Against Small-molecule EGFR Inhibitors.

Authors:  Bryson W Katona; Taylor Hojnacki; Rebecca A Glynn; Kayla E Paulosky; Katherine M Szigety; Yan Cao; Xuyao Zhang; Zijie Feng; Xin He; Jian Ma; Xianxin Hua
Journal:  Mol Cancer Ther       Date:  2020-09-02       Impact factor: 6.261
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.