Literature DB >> 28965914

Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome.

Maria D Torres1, Octavio Garcia2, Cindy Tang1, Jorge Busciglio3.   

Abstract

Abnormal dendritic spine structure and function is one of the most prominent features associated with neurodevelopmental disorders including Down syndrome (DS). Defects in both spine morphology and spine density may underlie alterations in neuronal and synaptic plasticity, ultimately affecting cognitive ability. Here we briefly examine the role of astrocytes in spine alterations and more specifically the involvement of astrocyte-secreted thrombospondin 1 (TSP-1) deficits in spine and synaptic pathology in DS.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer disease, dendritic spines; Astrocytes, intellectual disability; Dementia; Down syndrome; Interferon; Thrombospondin

Mesh：

Substances：

Year:  2017        PMID： 28965914      PMCID： PMC7185223          DOI： 10.1016/j.freeradbiomed.2017.09.025

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  70 in total

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