| Literature DB >> 28965749 |
Chunsik Lee1, Xuri Li2.
Abstract
The cardiovascular system is among the first organs formed during development and is pivotal for the formation and function of the rest of the organs and tissues. Therefore, the function and homeostasis of the cardiovascular system are finely regulated by many important molecules. Extensive studies have shown that platelet-derived growth factors (PDGFs) and their receptors are critical regulators of the cardiovascular system. Even though PDGF-C and PDGF-D are relatively new members of the PDGF family, their critical roles in the cardiovascular system as angiogenic and survival factors have been amply demonstrated. Understanding the functions of PDGF-C and PDGF-D and the signaling pathways involved may provide novel insights into both basic biomedical research and new therapeutic possibilities for the treatment of cardiovascular diseases.Entities:
Keywords: Cardiogenesis; Cardiovascular disease; PDGF-C; PDGF-D; Platelet-derived growth factor (PDGF); Vascular development
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Year: 2017 PMID： 28965749 DOI： 10.1016/j.mam.2017.09.005
Source DB: PubMed Journal: Mol Aspects Med ISSN： 0098-2997