Oksana Kamenskaya1, Asya Klinkova2, Irina Loginova1, Alexander Chernyavskiy3, Vladimir V Lomivorotov4, Alexander Karaskov5. 1. Department of Physiology, Siberian Biomedical Research Center Ministry of Health Russian Federation, 15 Rechkunovskaya Street, Novosibirsk, Russia, 630055. 2. Department of Physiology, Siberian Biomedical Research Center Ministry of Health Russian Federation, 15 Rechkunovskaya Street, Novosibirsk, Russia, 630055. klinkovaas@ngs.ru. 3. Department of Cardiac Surgery, Siberian Biomedical Research Center Ministry of Health Russian Federation, 15 Rechkunovskaya Street, Novosibirsk, Russia, 630055. 4. Department of Anesthesia and Intensive Care, Siberian Biomedical Research Center Ministry of Health Russian Federation, 15 Rechkunovskaya Street, Novosibirsk, Russia, 630055. 5. Siberian Biomedical Research Center Ministry of Health Russian Federation, 15 Rechkunovskaya Street, Novosibirsk, Russia, 630055.
Abstract
PURPOSE: To test the hypothesis that quality of life (QoL) parameters before surgery in patients with chronic thromboembolic pulmonary hypertension (CTEPH) are influenced by clinical determinants related to the underlying disease and to examine QoL parameters affected in the long-term after the operation by complications presenting in the early postoperative period. METHODS: This prospective cohort study included 128 patients who presented with CTEPH before and after pulmonary thromboendarterectomy (PTE; 1-year follow-up). All patients were examined regarding QoL using the Short-Form 36 Health Survey Questionnaire (SF-36). RESULTS: In patients with CTEPH, PTE provided immediate improvement in terms of pulmonary hemodynamic parameters and favorable effects on long-term outcome, including QoL 1 year after surgery. Multivariate analysis showed that systolic pulmonary arterial pressure, right ventricular ejection fraction, and the presence of coronary artery disease and chronic obstructive pulmonary disease (COPD) were independent factors affecting QoL on several SF-36 subscales in patients with CTEPH prior to surgery. The factors that affect patient QoL 1 year after surgery on some SF-36 subscales included the presence of coronary artery disease, COPD, heart failure, residual pulmonary hypertension, and prolonged ventilation, neurological complications in the early postoperative period of PTE. CONCLUSIONS: Surgical treatment for CTEPH leads to an increase in QoL in all SF-36 subscales, excluding general health perceptions. Factors affecting QoL in patients with CTEPH included severity of pulmonary arterial hypertension, comorbidity, and complications in the early postoperative period after PTE, such as heart failure, neurologic problems, residual pulmonary hypertension, and prolonged ventilation.
PURPOSE: To test the hypothesis that quality of life (QoL) parameters before surgery in patients with chronic thromboembolic pulmonary hypertension (CTEPH) are influenced by clinical determinants related to the underlying disease and to examine QoL parameters affected in the long-term after the operation by complications presenting in the early postoperative period. METHODS: This prospective cohort study included 128 patients who presented with CTEPH before and after pulmonary thromboendarterectomy (PTE; 1-year follow-up). All patients were examined regarding QoL using the Short-Form 36 Health Survey Questionnaire (SF-36). RESULTS: In patients with CTEPH, PTE provided immediate improvement in terms of pulmonary hemodynamic parameters and favorable effects on long-term outcome, including QoL 1 year after surgery. Multivariate analysis showed that systolic pulmonary arterial pressure, right ventricular ejection fraction, and the presence of coronary artery disease and chronic obstructive pulmonary disease (COPD) were independent factors affecting QoL on several SF-36 subscales in patients with CTEPH prior to surgery. The factors that affect patient QoL 1 year after surgery on some SF-36 subscales included the presence of coronary artery disease, COPD, heart failure, residual pulmonary hypertension, and prolonged ventilation, neurological complications in the early postoperative period of PTE. CONCLUSIONS: Surgical treatment for CTEPH leads to an increase in QoL in all SF-36 subscales, excluding general health perceptions. Factors affecting QoL in patients with CTEPH included severity of pulmonary arterial hypertension, comorbidity, and complications in the early postoperative period after PTE, such as heart failure, neurologic problems, residual pulmonary hypertension, and prolonged ventilation.
Authors: David P Jenkins; Michael Madani; Eckhard Mayer; Kim Kerr; Nic Kim; Walter Klepetko; Marco Morsolini; Philippe Dartevelle Journal: Eur Respir J Date: 2012-11-08 Impact factor: 16.671
Authors: P W Jones; G Brusselle; R W Dal Negro; M Ferrer; P Kardos; M L Levy; T Perez; J J Soler-Cataluña; T van der Molen; L Adamek; N Banik Journal: Respir Med Date: 2010-10-06 Impact factor: 3.415
Authors: Stuart W Jamieson; David P Kapelanski; Naohide Sakakibara; Gerard R Manecke; Patricia A Thistlethwaite; Kim M Kerr; Richard N Channick; Peter F Fedullo; William R Auger Journal: Ann Thorac Surg Date: 2003-11 Impact factor: 4.330
Authors: M Miravitlles; J L Alvarez-Sala; R Lamarca; M Ferrer; F Masa; H Verea; R Zalacain; C Murio; F Ros Journal: Qual Life Res Date: 2002-06 Impact factor: 4.147
Authors: Marion Delcroix; Irene Lang; Joanna Pepke-Zaba; Pavel Jansa; Andrea M D'Armini; Repke Snijder; Paul Bresser; Adam Torbicki; Sören Mellemkjaer; Jerzy Lewczuk; Iveta Simkova; Joan A Barberà; Marc de Perrot; Marius M Hoeper; Sean Gaine; Rudolf Speich; Miguel A Gomez-Sanchez; Gabor Kovacs; Xavier Jaïs; David Ambroz; Carmen Treacy; Marco Morsolini; David Jenkins; Jaroslav Lindner; Philippe Dartevelle; Eckhard Mayer; Gérald Simonneau Journal: Circulation Date: 2016-01-29 Impact factor: 29.690
Authors: Chunfeng Wang; Jie Yan; Jingyi Chen; Ying Wang; Ying Chun Lin; Rong Hu; Yong Wu Journal: Health Qual Life Outcomes Date: 2020-01-07 Impact factor: 3.186