Katja Kemp Jacobsen1, Elsebeth Lynge2, Anne Tjønneland3, Ilse Vejborg4, My von Euler-Chelpin2, Zorana J Andersen2. 1. Department of Technology, Faculty of Health and Technology, Metropolitan University College, Copenhagen, Denmark. katj@phmetropol.dk. 2. Centre for Epidemiology and Screening, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 3. Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. 4. Department of Radiology and Diagnostic Imaging Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Abstract
PURPOSE: We examined the association between alcohol consumption and mammographic density (MD) considering in detail the time of exposure and the type of alcohol. METHODS: Of 5,356 women (4,489 post-menopausal) from the Danish Diet, Cancer and Health cohort (1993-1997) who attended mammographic screening in Copenhagen (1993-2001), we used MD (mixed/dense or fatty) assessed at the first screening after cohort entry. Alcohol consumption was assessed at the time of recruitment. Logistic regression was used to estimate associations [odds ratios (OR), 95% confidence intervals (CI)] between alcohol consumption and MD. RESULTS: The mean age was 56.2 years, 56.5% of women had mixed/dense MD, and 91.8% were alcohol consumers. There was no association between current alcohol consumption and MD at baseline (age 50-65, on average 1 year before MD assessment) neither between age at drinking initiation and MD, in the fully adjusted model. There was a borderline statistically significantly increased OR of having mixed/dense MD in women who consumed > 7 drinks/week at age 20-29 (1.31, 95% CI 1.00-1.72) compared to non-drinkers in this age group, and no effect of drinking at age 30-39, 40-49 or after > 50 years, when adjusting for current drinking. However, when considering different types of alcohol, drinking spirits at age 20-29 was positively associated with mixed/dense breast (3-7 drinks/week: OR 1.74, 95% CI 1.12-2.72); >7 drinks/week: (OR 1.76, 95% CI 0.73-4.23). No consistent pattern was found with beer, wine, or fortified wine. CONCLUSIONS: We found higher MD among women with high alcohol consumption in early adulthood (ages 20-29), in those drinking spirits.
PURPOSE: We examined the association between alcohol consumption and mammographic density (MD) considering in detail the time of exposure and the type of alcohol. METHODS: Of 5,356 women (4,489 post-menopausal) from the Danish Diet, Cancer and Health cohort (1993-1997) who attended mammographic screening in Copenhagen (1993-2001), we used MD (mixed/dense or fatty) assessed at the first screening after cohort entry. Alcohol consumption was assessed at the time of recruitment. Logistic regression was used to estimate associations [odds ratios (OR), 95% confidence intervals (CI)] between alcohol consumption and MD. RESULTS: The mean age was 56.2 years, 56.5% of women had mixed/dense MD, and 91.8% were alcohol consumers. There was no association between current alcohol consumption and MD at baseline (age 50-65, on average 1 year before MD assessment) neither between age at drinking initiation and MD, in the fully adjusted model. There was a borderline statistically significantly increased OR of having mixed/dense MD in women who consumed > 7 drinks/week at age 20-29 (1.31, 95% CI 1.00-1.72) compared to non-drinkers in this age group, and no effect of drinking at age 30-39, 40-49 or after > 50 years, when adjusting for current drinking. However, when considering different types of alcohol, drinking spirits at age 20-29 was positively associated with mixed/dense breast (3-7 drinks/week: OR 1.74, 95% CI 1.12-2.72); >7 drinks/week: (OR 1.76, 95% CI 0.73-4.23). No consistent pattern was found with beer, wine, or fortified wine. CONCLUSIONS: We found higher MD among women with high alcohol consumption in early adulthood (ages 20-29), in those drinking spirits.
Entities:
Keywords:
Alcohol consumption; Breast cancer; Breast density; Mammographic density
Authors: Shadi Azam; Katja Kemp Jacobsen; Arja R Aro; My von Euler-Chelpin; Anne Tjønneland; Ilse Vejborg; Elsebeth Lynge; Zorana J Andersen Journal: Cancer Causes Control Date: 2018-09-07 Impact factor: 2.506
Authors: Xuan Huang; Gina Reye; Konstantin I Momot; Tony Blick; Thomas Lloyd; Wayne D Tilley; Theresa E Hickey; Cameron E Snell; Rachel K Okolicsanyi; Larisa M Haupt; Vito Ferro; Erik W Thompson; Honor J Hugo Journal: Front Cell Dev Biol Date: 2020-07-14