Literature DB >> 28964881

Clinical translation of stem cell based interventions for spinal cord injury - Are we there yet?

Harvinder S Chhabra1, Kanchan Sarda2.   

Abstract

Recent advances in basic science in research related to spinal cord injury (SCI) and regeneration have led to a variety of novel experimental therapeutics designed to promote functionally effective axonal regrowth and sprouting. Stem cell and other cellular interventions have gained lot of attention due to their immense potential of regeneration. These interventions have been tested for their efficacy in case of SCI both at the pre-clinical and clinical level. In this review we critically discuss the published literature on the cellular interventions for SCI and their clinical applications with respect to the strength of evidence established by these studies. The need to curb unethical practice of offering unproven stem cell "therapies" for SCI at a global level is also discussed.
Copyright © 2017. Published by Elsevier B.V.

Entities:  

Keywords:  Barriers to regeneration after SCI; Bone marrow; Cellular interventions; Clinical evidence; Clinical trials; Mesenchymal stem cells; Preclinical evidence; Unproven therapies

Mesh：

Year:  2017        PMID： 28964881     DOI： 10.1016/j.addr.2017.09.021

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  19 in total

Review 1.  Cellular therapy for treatment of spinal cord injury in Zebrafish model.

Authors:  Akram Tayanloo-Beik; Zahra Rabbani; Faezeh Soveyzi; Sepideh Alavi-Moghadam; Mostafa Rezaei-Tavirani; Parisa Goodarzi; Babak Arjmand; Bagher Larijani
Journal:  Mol Biol Rep       Date:  2021-01-18       Impact factor: 2.316

2.  Intramedullary cervical spinal mass after stem cell transplantation using an olfactory mucosal cell autograft.

Authors:  Claire F Woodworth; Gregory Jenkins; Jane Barron; Nanette Hache
Journal:  CMAJ       Date:  2019-07-08       Impact factor: 8.262

Review 3.  Regenerative Therapies for Spinal Cord Injury.

Authors:  Nureddin Ashammakhi; Han-Jun Kim; Arshia Ehsanipour; Rebecca D Bierman; Outi Kaarela; Chengbin Xue; Ali Khademhosseini; Stephanie K Seidlits
Journal:  Tissue Eng Part B Rev       Date:  2019-10-23       Impact factor: 6.389

Review 4.  Stem cell/cellular interventions in human spinal cord injury: Is it time to move from guidelines to regulations and legislations? Literature review and Spinal Cord Society position statement.

Authors:  Harvinder S Chhabra; Kanchan Sarda; Geeta Jotwani; M Gourie-Devi; Erkan Kaptanoglu; Susan Charlifue; S L Yadav; B Mohapatra; Abhishek Srivastava; Kedar Phadke
Journal:  Eur Spine J       Date:  2019-05-16       Impact factor: 3.134

5.  Human Adipose-Derived Stem Cells Combined with Nano-Hydrogel Promote Functional Recovery after Spinal Cord Injury in Rats.

Authors:  Jianping Li; Zhisheng Ji; Yu Wang; Tiantian Li; Jinghua Luo; Jun Li; Xueshuang Shi; Liming Li; Liumin He; Wutian Wu
Journal:  Biology (Basel)       Date:  2022-05-20

6.  Reconstructing the severed spinal cord.

Authors:  Sergio Canavero; Xiaoping Ren; C-Yoon Kim
Journal:  Surg Neurol Int       Date:  2017-11-21

Review 7.  The Emerging Role of lncRNAs in Spinal Cord Injury.

Authors:  Fei Wang; Junzhi Liu; Xiunan Wang; Jigang Chen; Qingjie Kong; Baoguo Ye; Zhenxing Li
Journal:  Biomed Res Int       Date:  2019-10-15       Impact factor: 3.411

Review 8.  Biomaterial-supported MSC transplantation enhances cell-cell communication for spinal cord injury.

Authors:  Bin Lv; Xing Zhang; Jishan Yuan; Yongxin Chen; Hua Ding; Xinbing Cao; Anquan Huang
Journal:  Stem Cell Res Ther       Date:  2021-01-07       Impact factor: 6.832

9.  Hypoxia Response Element-Directed Expression of aFGF in Neural Stem Cells Promotes the Recovery of Spinal Cord Injury and Attenuates SCI-Induced Apoptosis.

Authors:  Yibo Ying; Yifan Zhang; Yurong Tu; Min Chen; Zhiyang Huang; Weiyang Ying; Qiuji Wu; Jiahui Ye; Ziyue Xiang; Xiangyang Wang; Zhouguang Wang; Sipin Zhu
Journal:  Front Cell Dev Biol       Date:  2021-06-14

10.  Tubular scaffold with microchannels and an H-shaped lumen loaded with bone marrow stromal cells promotes neuroregeneration and inhibits apoptosis after spinal cord injury.

Authors:  Xue Chen; Jian Wu; Rongcheng Sun; Yahong Zhao; Yi Li; Jingying Pan; Ying Chen; Xiaodong Wang
Journal:  J Tissue Eng Regen Med       Date:  2020-01-29       Impact factor: 3.963
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