Literature DB >> 28964631

A Tale of Two Elabela Null Mice.

Irinna Papangeli1, Hyung J Chun2.   

Abstract

Elabela (ELA), the second peptide ligand for the apelin receptor, APLNR, was previously found in lower vertebrates to be crucial for endoderm and cardiac development. Two new studies report on the phenotypes of Ela null mice, ranging from defective embryogenesis to preeclampsia, providing new insights and raising greater intrigue on this cardiometabolic pathway.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  APLNR signaling; GPCR; embryo development; preeclampsia

Mesh：

Substances：

Year:  2017        PMID： 28964631      PMCID： PMC5673578          DOI： 10.1016/j.tem.2017.09.004

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  10 in total

1.  Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.

Authors:  Keiji Kuba; Liyong Zhang; Yumiko Imai; Sara Arab; Manyin Chen; Yuichiro Maekawa; Michael Leschnik; Andreas Leibbrandt; Mato Markovic; Mato Makovic; Julia Schwaighofer; Nadine Beetz; Renata Musialek; G Greg Neely; Vukoslav Komnenovic; Ursula Kolm; Bernhard Metzler; Romeo Ricci; Hiromitsu Hara; Arabella Meixner; Mai Nghiem; Xin Chen; Fayez Dawood; Kit Man Wong; Renu Sarao; Eva Cukerman; Akinori Kimura; Lutz Hein; Johann Thalhammer; Peter P Liu; Josef M Penninger
Journal:  Circ Res       Date:  2007-08-02       Impact factor: 17.367

2.  Toddler: an embryonic signal that promotes cell movement via Apelin receptors.

Authors:  Andrea Pauli; Megan L Norris; Eivind Valen; Guo-Liang Chew; James A Gagnon; Steven Zimmerman; Andrew Mitchell; Jiao Ma; Julien Dubrulle; Deepak Reyon; Shengdar Q Tsai; J Keith Joung; Alan Saghatelian; Alexander F Schier
Journal:  Science       Date:  2014-01-09       Impact factor: 47.728

3.  ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.

Authors:  Lena Ho; Marie van Dijk; Sam Tan Jian Chye; Daniel M Messerschmidt; Serene C Chng; Sheena Ong; Ling Ka Yi; Souad Boussata; Grace Hui-Yi Goh; Gijs B Afink; Chin Yan Lim; N Ray Dunn; Davor Solter; Barbara B Knowles; Bruno Reversade
Journal:  Science       Date:  2017-06-29       Impact factor: 47.728

4.  ELABELA: a hormone essential for heart development signals via the apelin receptor.

Authors:  Serene C Chng; Lena Ho; Jing Tian; Bruno Reversade
Journal:  Dev Cell       Date:  2013-12-05       Impact factor: 12.270

5.  ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

Authors:  Lena Ho; Shawn Y X Tan; Sheena Wee; Yixuan Wu; Sam J C Tan; Navin B Ramakrishna; Serene C Chng; Srikanth Nama; Iwona Szczerbinska; Iwona Sczerbinska; Yun-Shen Chan; Stuart Avery; Norihiro Tsuneyoshi; Huck Hui Ng; Jayantha Gunaratne; N Ray Dunn; Bruno Reversade
Journal:  Cell Stem Cell       Date:  2015-09-17       Impact factor: 24.633

6.  Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.

Authors:  Laina Freyer; Chih-Wei Hsu; Sonja Nowotschin; Andrea Pauli; Junji Ishida; Keiji Kuba; Akiyoshi Fukamizu; Alexander F Schier; Pamela A Hoodless; Mary E Dickinson; Anna-Katerina Hadjantonakis
Journal:  Cell Rep       Date:  2017-08-29       Impact factor: 9.423

7.  Apelin stimulates glucose utilization in normal and obese insulin-resistant mice.

Authors:  Cédric Dray; Claude Knauf; Danièle Daviaud; Aurélie Waget; Jérémie Boucher; Marie Buléon; Patrice D Cani; Camille Attané; Charlotte Guigné; Christian Carpéné; Rémy Burcelin; Isabelle Castan-Laurell; Philippe Valet
Journal:  Cell Metab       Date:  2008-11       Impact factor: 27.287

8.  Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis.

Authors:  Hyung J Chun; Ziad A Ali; Yoko Kojima; Ramendra K Kundu; Ahmad Y Sheikh; Rani Agrawal; Lixin Zheng; Nicholas J Leeper; Nathan E Pearl; Andrew J Patterson; Joshua P Anderson; Philip S Tsao; Michael J Lenardo; Euan A Ashley; Thomas Quertermous
Journal:  J Clin Invest       Date:  2008-10       Impact factor: 14.808

9.  Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.

Authors:  Yujung Kang; Jongmin Kim; Joshua P Anderson; Jingxia Wu; Scott R Gleim; Ramendra K Kundu; Danielle L McLean; Jun-dae Kim; Hyekyung Park; Suk-won Jin; John Hwa; Thomas Quertermous; Hyung J Chun
Journal:  Circ Res       Date:  2013-04-19       Impact factor: 17.367

10.  MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation.

Authors:  Irinna Papangeli; Jongmin Kim; Inna Maier; Saejeong Park; Aram Lee; Yujung Kang; Keiichiro Tanaka; Omar F Khan; Hyekyung Ju; Yoko Kojima; Kristy Red-Horse; Daniel G Anderson; Arndt F Siekmann; Hyung J Chun
Journal:  Nat Commun       Date:  2016-04-12       Impact factor: 14.919
  10 in total

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