Literature DB >> 28964549

Evidence-Based Precision Oncology with the Cancer Targetome.

Aurora S Blucher1, Gabrielle Choonoo2, Molly Kulesz-Martin3, Guanming Wu1, Shannon K McWeeney4.   

Abstract

A core tenet of precision oncology is the rational choice of drugs to interact with patient-specific biological targets of interest, but it is currently difficult for researchers to obtain consistent and well-supported target information for pharmaceutical drugs. We review current drug-target interaction resources and critically assess how supporting evidence is handled. We introduce the concept of a unified Cancer Targetome to aggregate drug-target interactions in an evidence-based framework. We discuss current unmet needs and the implications for evidence-based clinical omics. The focus of this review is precision oncology but the discussion is highly relevant to targeted therapies in any area.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cancer Targetome; data curation; evidence-based medicine; molecular targeted therapy; precision medicine

Mesh：

Year:  2017        PMID： 28964549      PMCID： PMC5759325          DOI： 10.1016/j.tips.2017.08.006

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  71 in total

1.  Comprehensive analysis of kinase inhibitor selectivity.

Authors:  Mindy I Davis; Jeremy P Hunt; Sanna Herrgard; Pietro Ciceri; Lisa M Wodicka; Gabriel Pallares; Michael Hocker; Daniel K Treiber; Patrick P Zarrinkar
Journal:  Nat Biotechnol       Date:  2011-10-30       Impact factor: 54.908

2.  Global mapping of pharmacological space.

Authors:  Gaia V Paolini; Richard H B Shapland; Willem P van Hoorn; Jonathan S Mason; Andrew L Hopkins
Journal:  Nat Biotechnol       Date:  2006-07       Impact factor: 54.908

3.  Genomic sciences and the medicine of tomorrow.

Authors:  J Drews
Journal:  Nat Biotechnol       Date:  1996-11       Impact factor: 54.908

Review 4.  FDA-approved small-molecule kinase inhibitors.

Authors:  Peng Wu; Thomas E Nielsen; Mads H Clausen
Journal:  Trends Pharmacol Sci       Date:  2015-05-12       Impact factor: 14.819

5.  Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery.

Authors:  Yuan Wang; Allen Cornett; Fred J King; Yi Mao; Florian Nigsch; C Gregory Paris; Gregory McAllister; Jeremy L Jenkins
Journal:  Cell Chem Biol       Date:  2016-07-14       Impact factor: 8.116

6.  Structure and chemical inhibition of the RET tyrosine kinase domain.

Authors:  Phillip P Knowles; Judith Murray-Rust; Svend Kjaer; Rizaldy P Scott; Sarah Hanrahan; Massimo Santoro; Carlos F Ibáñez; Neil Q McDonald
Journal:  J Biol Chem       Date:  2006-08-23       Impact factor: 5.157

7.  The druggable genome and support for target identification and validation in drug development.

Authors:  Chris Finan; Anna Gaulton; Felix A Kruger; R Thomas Lumbers; Tina Shah; Jorgen Engmann; Luana Galver; Ryan Kelley; Anneli Karlsson; Rita Santos; John P Overington; Aroon D Hingorani; Juan P Casas
Journal:  Sci Transl Med       Date:  2017-03-29       Impact factor: 17.956

8.  PubChem's BioAssay Database.

Authors:  Yanli Wang; Jewen Xiao; Tugba O Suzek; Jian Zhang; Jiyao Wang; Zhigang Zhou; Lianyi Han; Karen Karapetyan; Svetlana Dracheva; Benjamin A Shoemaker; Evan Bolton; Asta Gindulyte; Stephen H Bryant
Journal:  Nucleic Acids Res       Date:  2011-12-02       Impact factor: 16.971

9.  Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer.

Authors:  Rafael Guerrero-Preston; Christina Michailidi; Luigi Marchionni; Curtis R Pickering; Mitchell J Frederick; Jeffrey N Myers; Srinivasan Yegnasubramanian; Tal Hadar; Maartje G Noordhuis; Veronika Zizkova; Elana Fertig; Nishant Agrawal; William Westra; Wayne Koch; Joseph Califano; Victor E Velculescu; David Sidransky
Journal:  Epigenetics       Date:  2014-05-01       Impact factor: 4.528

10.  PubChem BioAssay: 2014 update.

Authors:  Yanli Wang; Tugba Suzek; Jian Zhang; Jiyao Wang; Siqian He; Tiejun Cheng; Benjamin A Shoemaker; Asta Gindulyte; Stephen H Bryant
Journal:  Nucleic Acids Res       Date:  2013-11-05       Impact factor: 16.971
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  11 in total

1.  Montagna Symposium 2017-Precision Dermatology: Next Generation Prevention, Diagnosis, and Treatment.

Authors:  Jakub Tolar; Johann W Bauer; Daniel H Kaplan; Sancy A Leachman; John A McGrath; Amy S Paller; Kelly A Griffith-Bauer; Clara E Stemwedel; Molly F Kulesz-Martin
Journal:  J Invest Dermatol       Date:  2018-05-02       Impact factor: 8.551

2.  Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.

Authors:  Daniel Bottomly; Nicola Long; Anna Reister Schultz; Stephen E Kurtz; Cristina E Tognon; Kara Johnson; Melissa Abel; Anupriya Agarwal; Sammantha Avaylon; Erik Benton; Aurora Blucher; Uma Borate; Theodore P Braun; Jordana Brown; Jade Bryant; Russell Burke; Amy Carlos; Bill H Chang; Hyun Jun Cho; Stephen Christy; Cody Coblentz; Aaron M Cohen; Amanda d'Almeida; Rachel Cook; Alexey Danilov; Kim-Hien T Dao; Michie Degnin; James Dibb; Christopher A Eide; Isabel English; Stuart Hagler; Heath Harrelson; Rachel Henson; Hibery Ho; Sunil K Joshi; Brian Junio; Andy Kaempf; Yoko Kosaka; Ted Laderas; Matt Lawhead; Hyunjung Lee; Jessica T Leonard; Chenwei Lin; Evan F Lind; Selina Qiuying Liu; Pierrette Lo; Marc M Loriaux; Samuel Luty; Julia E Maxson; Tara Macey; Jacqueline Martinez; Jessica Minnier; Andrea Monteblanco; Motomi Mori; Quinlan Morrow; Dylan Nelson; Justin Ramsdill; Angela Rofelty; Alexandra Rogers; Kyle A Romine; Peter Ryabinin; Jennifer N Saultz; David A Sampson; Samantha L Savage; Robert Schuff; Robert Searles; Rebecca L Smith; Stephen E Spurgeon; Tyler Sweeney; Ronan T Swords; Aashis Thapa; Karina Thiel-Klare; Elie Traer; Jake Wagner; Beth Wilmot; Joelle Wolf; Guanming Wu; Amy Yates; Haijiao Zhang; Christopher R Cogle; Robert H Collins; Michael W Deininger; Christopher S Hourigan; Craig T Jordan; Tara L Lin; Micaela E Martinez; Rachel R Pallapati; Daniel A Pollyea; Anthony D Pomicter; Justin M Watts; Scott J Weir; Brian J Druker; Shannon K McWeeney; Jeffrey W Tyner
Journal:  Cancer Cell       Date:  2022-07-21       Impact factor: 38.585

Review 3.  Advances in multiple omics of natural-killer/T cell lymphoma.

Authors:  Jie Xiong; Wei-Li Zhao
Journal:  J Hematol Oncol       Date:  2018-12-04       Impact factor: 17.388

4.  Natural Product Target Network Reveals Potential for Cancer Combination Therapies.

Authors:  Steven R Chamberlin; Aurora Blucher; Guanming Wu; Lynne Shinto; Gabrielle Choonoo; Molly Kulesz-Martin; Shannon McWeeney
Journal:  Front Pharmacol       Date:  2019-05-31       Impact factor: 5.810

5.  Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models.

Authors:  Xiaoming Ouyang; Ashley Barling; Aletha Lesch; Jeffrey W Tyner; Gabrielle Choonoo; Christina Zheng; Sophia Jeng; Toni M West; Daniel Clayburgh; Sara A Courtneidge; Shannon K McWeeney; Molly Kulesz-Martin
Journal:  Cancer Biol Ther       Date:  2018-08-17       Impact factor: 4.742

6.  Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma.

Authors:  Gabrielle Choonoo; Aurora S Blucher; Samuel Higgins; Mitzi Boardman; Sophia Jeng; Christina Zheng; James Jacobs; Ashley Anderson; Steven Chamberlin; Nathaniel Evans; Myles Vigoda; Benjamin Cordier; Jeffrey W Tyner; Molly Kulesz-Martin; Shannon K McWeeney; Ted Laderas
Journal:  PLoS One       Date:  2019-10-09       Impact factor: 3.240

7.  Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz.

Authors:  Aurora S Blucher; Shannon K McWeeney; Lincoln Stein; Guanming Wu
Journal:  F1000Res       Date:  2019-06-20

8.  The ZNF750-RAC1 axis as potential prognostic factor for breast cancer.

Authors:  Alessio Butera; Matteo Cassandri; Francesco Rugolo; Massimiliano Agostini; Gerry Melino
Journal:  Cell Death Discov       Date:  2020-11-29

9.  Functional genomic landscape of acute myeloid leukaemia.

Authors:  Jeffrey W Tyner; Cristina E Tognon; Daniel Bottomly; Beth Wilmot; Stephen E Kurtz; Samantha L Savage; Nicola Long; Anna Reister Schultz; Elie Traer; Melissa Abel; Anupriya Agarwal; Aurora Blucher; Uma Borate; Jade Bryant; Russell Burke; Amy Carlos; Richie Carpenter; Joseph Carroll; Bill H Chang; Cody Coblentz; Amanda d'Almeida; Rachel Cook; Alexey Danilov; Kim-Hien T Dao; Michie Degnin; Deirdre Devine; James Dibb; David K Edwards; Christopher A Eide; Isabel English; Jason Glover; Rachel Henson; Hibery Ho; Abdusebur Jemal; Kara Johnson; Ryan Johnson; Brian Junio; Andy Kaempf; Jessica Leonard; Chenwei Lin; Selina Qiuying Liu; Pierrette Lo; Marc M Loriaux; Samuel Luty; Tara Macey; Jason MacManiman; Jacqueline Martinez; Motomi Mori; Dylan Nelson; Ceilidh Nichols; Jill Peters; Justin Ramsdill; Angela Rofelty; Robert Schuff; Robert Searles; Erik Segerdell; Rebecca L Smith; Stephen E Spurgeon; Tyler Sweeney; Aashis Thapa; Corinne Visser; Jake Wagner; Kevin Watanabe-Smith; Kristen Werth; Joelle Wolf; Libbey White; Amy Yates; Haijiao Zhang; Christopher R Cogle; Robert H Collins; Denise C Connolly; Michael W Deininger; Leylah Drusbosky; Christopher S Hourigan; Craig T Jordan; Patricia Kropf; Tara L Lin; Micaela E Martinez; Bruno C Medeiros; Rachel R Pallapati; Daniel A Pollyea; Ronan T Swords; Justin M Watts; Scott J Weir; David L Wiest; Ryan M Winters; Shannon K McWeeney; Brian J Druker
Journal:  Nature       Date:  2018-10-17       Impact factor: 49.962

10.  Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma.

Authors:  Ashley N Anderson; Danielle McClanahan; James Jacobs; Sophia Jeng; Myles Vigoda; Aurora S Blucher; Christina Zheng; Yeon Jung Yoo; Carolyn Hale; Xiaoming Ouyang; Daniel Clayburgh; Peter Andersen; Jeffrey W Tyner; Anna Bar; Olivia M Lucero; Justin J Leitenberger; Shannon K McWeeney; Molly Kulesz-Martin
Journal:  Cold Spring Harb Mol Case Stud       Date:  2020-08-25
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