Davide Lombardi1, Alberto Paderno1, Davide Giordano2, Diego Barbieri3, Stefano Taboni1, Cesare Piazza1, Carlo Cappelli4, Francesco Bertagna5, Verter Barbieri2, Simonetta Piana6, Salvatore Bellafiore6, Giuseppe Spriano7, Giuseppe Mercante7, Piero Nicolai1. 1. Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy. 2. Otolaryngology Unit, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy. 3. Department of Otorhinolaryngology - Head and Neck Surgery, University "San Raffaele", Milan, Italy. 4. Endocrine and Metabolic Unit, University of Brescia, Brescia, Italy. 5. Department of Nuclear Medicine, University of Brescia, Brescia, Italy. 6. Pathology Unit, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy. 7. Department of Otorhinolaryngology - Head and Neck Surgery, Istituto Nazionale dei Tumori "Regina Elena", Rome, Italy.
Abstract
BACKGROUND: Neck dissection is considered the treatment of choice in patients with lateral neck metastases from well-differentiated thyroid cancer. METHODS: A multicenter, retrospective review of patients who underwent therapeutic lateral neck dissection for well-differentiated thyroid carcinoma was carried out. RESULTS: The study included a total of 405 lateral neck dissections performed in 352 patients; 197 women (56%) and 155 men (44%). When considering ipsilateral neck metastases, levels IIa, IIb, III, IV, Va, Vb, and V (not otherwise specified) were involved in 42%, 6%, 73%, 67%, 11%, 31%, and 35% of cases, respectively. Five-year and 10-year overall survival (OS) were 93% and 81%, respectively. Age >55 years, pathologic T (pT)4 category, tumor diameter >4 cm, aggressive variants of well-differentiated thyroid carcinoma, endovascular invasion, and number of positive nodes >5 turned out to be the most important prognostic factors. CONCLUSION: Neck dissection is a valid treatment option in the presence of neck metastasis from well-differentiated thyroid carcinoma. Levels IIa, III, IV, and Vb should always be removed.
BACKGROUND: Neck dissection is considered the treatment of choice in patients with lateral neck metastases from well-differentiated thyroid cancer. METHODS: A multicenter, retrospective review of patients who underwent therapeutic lateral neck dissection for well-differentiated thyroid carcinoma was carried out. RESULTS: The study included a total of 405 lateral neck dissections performed in 352 patients; 197 women (56%) and 155 men (44%). When considering ipsilateral neck metastases, levels IIa, IIb, III, IV, Va, Vb, and V (not otherwise specified) were involved in 42%, 6%, 73%, 67%, 11%, 31%, and 35% of cases, respectively. Five-year and 10-year overall survival (OS) were 93% and 81%, respectively. Age >55 years, pathologic T (pT)4 category, tumor diameter >4 cm, aggressive variants of well-differentiated thyroid carcinoma, endovascular invasion, and number of positive nodes >5 turned out to be the most important prognostic factors. CONCLUSION: Neck dissection is a valid treatment option in the presence of neck metastasis from well-differentiated thyroid carcinoma. Levels IIa, III, IV, and Vb should always be removed.
Authors: Emilien Chebib; Caroline Eymerit; Nathalie Chabbert-Buffet; Bruno Angelard; Jean Lacau St Guily; Sophie Périé Journal: Gland Surg Date: 2020-12
Authors: Giovanna Di Meo; Francesco Paolo Prete; Giuseppe Massimiliano De Luca; Alessandro Pasculli; Lucia Ilaria Sgaramella; Francesco Minerva; Francesco Antonio Logoluso; Giovanna Calculli; Angela Gurrado; Mario Testini Journal: Cancers (Basel) Date: 2021-05-31 Impact factor: 6.639