Riad A Sulimani1, Ashry G Mohammed2, Suliman N Alshehri3, Assim A Alfadda4, Abdulaziz Al-Othman5, Aliya A Khan6. 1. Department of Medicine, College of Medicine, King Saud University, Riyadh, 7805, Saudi Arabia. rsulimani@ksu.edu.sa. 2. Department of Community and Family Medicine, College of Medicine, King Saud University, Riyadh, 7805, Saudi Arabia. 3. Department of School Health, Ministry of Health, Riyadh, Saudi Arabia. 4. Obesity Research Center, College of Medicine, King Saud University, Riyadh, 7805, Saudi Arabia. 5. Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 12372, Saudi Arabia. 6. Divisions Endocrinology and Geriatrics, McMaster University, 331-209 Sheddon Drive, Oakville, ON, L6J 1X8, Canada.
Abstract
This study examined the effects of weekly 35,000 IU vitamin D supplementation for 4 weeks on bone turnover markers (BTMs). There was improvement in the levels of parathyroid hormone (PTH), osteocalcin, and carboxy-terminal telopeptides of crosslinks of type 1 collagen (βCTX) which paralleled the increase in vitamin D levels. PURPOSE: The effects of vitamin D supplementation on bone turnover markers (BTMs) have been inconsistent. This study examined the effects of weekly 35,000 IU vitamin D supplementation for 1 month on BTMs. METHODS: Sixty-eight vitamin D deficient adolescent females were given 35,000 IU of vitamin D3 for 4 weeks. Pre and post intervention blood samples were taken for 25(OH) D, PTH, osteocalcin and βCTX. RESULTS: There was a significant increase in serum 25 (OH) D in the post intervention period which was accompanied by a significant decrease in PTH, osteocalcin and βCTX (P < 0.001). CONCLUSIONS: We concluded that weekly 35,000 IU vitamin D supplementation for 4 weeks results in significant improvement of BTMs.
This study examined the effects of weekly 35,000 IU vitamin D supplementation for 4 weeks on bone turnover markers (BTMs). There was improvement in the levels of parathyroid hormone (PTH), osteocalcin, and carboxy-terminal telopeptides of crosslinks of type 1 collagen (βCTX) which paralleled the increase in vitamin D levels. PURPOSE: The effects of vitamin D supplementation on bone turnover markers (BTMs) have been inconsistent. This study examined the effects of weekly 35,000 IU vitamin D supplementation for 1 month on BTMs. METHODS: Sixty-eight vitamin D deficient adolescent females were given 35,000 IU of vitamin D3 for 4 weeks. Pre and post intervention blood samples were taken for 25(OH) D, PTH, osteocalcin and βCTX. RESULTS: There was a significant increase in serum 25 (OH) D in the post intervention period which was accompanied by a significant decrease in PTH, osteocalcin and βCTX (P < 0.001). CONCLUSIONS: We concluded that weekly 35,000 IU vitamin D supplementation for 4 weeks results in significant improvement of BTMs.
Entities:
Keywords:
Adolescents; Bone turnover markers; Vitamin D deficiency
Authors: Nora A AlFaris; Nora M AlKehayez; Fatema I AlMushawah; AbdulRhman N AlNaeem; Nadia D AlAmri; Ebtisam S AlMudawah Journal: Sci Rep Date: 2019-12-30 Impact factor: 4.379