Rikke Langballe1, Esther M John2,3, Kathleen E Malone4, Leslie Bernstein5, Julia A Knight6,7, Charles F Lynch8, Rebecca M Howell9, Roy Shore10, Meghan Woods11, Patrick Concannon12, Jonine L Bernstein11, Lene Mellemkjær13. 1. Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark. 2. Cancer Prevention Institute of California, Fremont, CA, USA. 3. Department of Health Research and Policy (Epidemiology) and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. 4. Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 5. Beckman Research Institute of the City of Hope, Duarte, CA, USA. 6. Sinai Health System, Lunenfeld-Tanenbaum Research Institute, Toronto, Canada. 7. Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. 8. University of Iowa, Iowa City, IA, USA. 9. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 10. New York University School of Medicine, New York, NY, USA. 11. Memorial Sloan Kettering Cancer Center, New York, NY, USA. 12. Genetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA. 13. Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark. lene@cancer.dk.
Abstract
PURPOSE: We examined the degree of over- and under-reporting of cardiovascular diseases (CVDs) among female breast cancer survivors comparing self-reports to diagnostic codes from the Danish National Patient Register (NPR). METHODS: The study comprised 357 Danish breast cancer patients from the WECARE study who completed a telephone interview concerning CVDs. Disease diagnoses for these women were obtained from the NPR. Agreement was calculated as the number of diagnoses that were both self-reported and in the NPR divided by (1) number of self-reported diagnoses (over-reporting) or (2) number of diagnoses in the NPR (under-reporting). RESULTS: In total, 68 women reported 96 specific cardiovascular outcomes of which 56 (58%) were found in the NPR. Ninety cardiovascular diagnoses were found in the NPR of which 56 (62%) were specifically reported at the interview. There was 80% agreement as to the occurrence of a cardiovascular diagnosis overall. Of 289 women reporting no CVD, 273 (94%) had no diagnoses in the NPR. CONCLUSIONS: Breast cancer survivors seem to report absence of CVD accurately, but they both over-report and under-report specific cardiovascular diagnoses. Using a broader definition of CVDs improves the agreement between self-reported and NPR data. IMPLICATIONS FOR CANCER SURVIVORS: Determining how cancer treatments affect the risk of cardiovascular morbidities is essential, and the development of high-quality methods for collecting such data is critical. While self-reported data are adequate for assessing the presence of any CVD condition, medical record review will yield higher quality data on specific CVD conditions.
PURPOSE: We examined the degree of over- and under-reporting of cardiovascular diseases (CVDs) among female breast cancer survivors comparing self-reports to diagnostic codes from the Danish National Patient Register (NPR). METHODS: The study comprised 357 Danish breast cancerpatients from the WECARE study who completed a telephone interview concerning CVDs. Disease diagnoses for these women were obtained from the NPR. Agreement was calculated as the number of diagnoses that were both self-reported and in the NPR divided by (1) number of self-reported diagnoses (over-reporting) or (2) number of diagnoses in the NPR (under-reporting). RESULTS: In total, 68 women reported 96 specific cardiovascular outcomes of which 56 (58%) were found in the NPR. Ninety cardiovascular diagnoses were found in the NPR of which 56 (62%) were specifically reported at the interview. There was 80% agreement as to the occurrence of a cardiovascular diagnosis overall. Of 289 women reporting no CVD, 273 (94%) had no diagnoses in the NPR. CONCLUSIONS:Breast cancer survivors seem to report absence of CVD accurately, but they both over-report and under-report specific cardiovascular diagnoses. Using a broader definition of CVDs improves the agreement between self-reported and NPR data. IMPLICATIONS FOR CANCER SURVIVORS: Determining how cancer treatments affect the risk of cardiovascular morbidities is essential, and the development of high-quality methods for collecting such data is critical. While self-reported data are adequate for assessing the presence of any CVD condition, medical record review will yield higher quality data on specific CVD conditions.
Entities:
Keywords:
Breast cancer survivors; Cardiovascular disease; Validation study
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