The first case of cutaneous phaeohyphomycosis caused by Bipolaris spicifera in Northern China: A case report.

Phaeohyphomycosis (PHM) is a term used to describe any fungus presenting in tissues with pseudohyphae, hyphae, brown yeast-like cells or a combination of these forms. Sinusitis and skin infections are the most common presentation of subcutaneous PHM caused by the fungus Bipolaris spicifera. However, the majority of cases have so far been encountered in tropical climatic zones. The present study documents a case of subcutaneous PHM caused by infection with Bipolaris spicifera in a 56-year-old Chinese man, who presented with plaque papillomatosis on the left foot. The organism isolated from the lesion scar and tissue was identified as Bipolaris spicifera by its morphology, histopathology and DNA sequencing. The patient was successfully treated with itraconazole and terbinafine.