Yasushi Yamasaki 1 , Noriya Uedo 1 , Yoji Takeuchi 1 , Koji Higashino 1 , Noboru Hanaoka 1 , Tomofumi Akasaka 1 , Minoru Kato 1 , Kenta Hamada 1 , Yusuke Tonai 1 , Noriko Matsuura 1 , Takashi Kanesaka 1 , Masamichi Arao 1 , Sho Suzuki 1 , Taro Iwatsubo 1 , Satoki Shichijo 1 , Hiroko Nakahira 1 , Ryu Ishihara 1 , Hiroyasu Iishi 1 Show Affiliations »
Abstract
BACKGROUND AND STUDY AIM: Underwater endoscopic mucosal resection (UEMR) was recently developed in a Western country. A prospective cohort study to investigate the effectiveness of UEMR was conducted in patients with small superficial nonampullary duodenal adenomas. PATIENTS AND METHODS: Patients with duodenal adenomas ≤ 20 mm were enrolled. After the duodenal lumen had been filled with physiological saline, UEMR was performed without submucosal injection. Endoclip closure was attempted for all mucosal defects after UEMR. Follow-up endoscopy with biopsy was performed 3 months later. The primary end point was the complete resection rate, defined as neither endoscopic nor histological residue of adenoma at the follow-up endoscopy. RESULTS: 30 patients with 31 lesions were enrolled. The mean (SD) tumor size was 12.0 mm (7.3). The complete resection rate was 97 % (90 % confidence interval, 87 % - 99 %). The en bloc resection rate was 87 %. All mucosal defects were successfully closed by endoclips. No adverse events occurred except for one case of mild aspiration pneumonia. CONCLUSIONS: UEMR is efficacious for the treatment of small duodenal adenomas, but further large-scale trials are warranted to confirm these results. © Georg Thieme Verlag KG Stuttgart · New York.
BACKGROUND AND STUDY AIM: Underwater endoscopic mucosal resection (UEMR) was recently developed in a Western country. A prospective cohort study to investigate the effectiveness of UEMR was conducted in patients with small superficial nonampullary duodenal adenomas . PATIENTS AND METHODS: Patients with duodenal adenomas ≤ 20 mm were enrolled. After the duodenal lumen had been filled with physiological saline , UEMR was performed without submucosal injection. Endoclip closure was attempted for all mucosal defects after UEMR. Follow-up endoscopy with biopsy was performed 3 months later. The primary end point was the complete resection rate, defined as neither endoscopic nor histological residue of adenoma at the follow-up endoscopy. RESULTS: 30 patients with 31 lesions were enrolled. The mean (SD) tumor size was 12.0 mm (7.3). The complete resection rate was 97 % (90 % confidence interval, 87 % - 99 %). The en bloc resection rate was 87 %. All mucosal defects were successfully closed by endoclips. No adverse events occurred except for one case of mild aspiration pneumonia . CONCLUSIONS: UEMR is efficacious for the treatment of small duodenal adenomas , but further large-scale trials are warranted to confirm these results. © Georg Thieme Verlag KG Stuttgart · New York.
Entities: Chemical
Disease
Species
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Year: 2017
PMID： 28962044 DOI： 10.1055/s-0043-119214
Source DB: PubMed Journal: Endoscopy ISSN： 0013-726X Impact factor: 10.093