| Literature DB >> 28961752 |
Silvio Danese1,2, Federica Furfaro1, Stefania Vetrano1,2.
Abstract
Sphingosine 1 phosphate [S1P] is a bioactive lipid mediator involved in the regulation of several cellular processes though the activation of a G protein-coupled receptor family known as the S1P receptors [S1PRs]. Advances in the understanding of the biological activities mediated by S1PRs have sparked great interest in the S1P/S1PRs axes as new therapeutic targets for the modulation of several cellular processes. In particular, the S1P/S1PR1 axis has been identified as key regulator for lymphocyte migration from lymph nodes. The blockade of this axis is emerging as a new therapeutic approach to control the aberrant leukocyte migration into the mucosa in inflammatory bowel disease [IBD]. This review briefly summarises the current evidence coming from clinical studies, and discusses the future prospects of S1P inhibitors for treatment of inflammatory bowel disease.Entities:
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Year: 2018 PMID： 28961752 DOI： 10.1093/ecco-jcc/jjx107
Source DB: PubMed Journal: J Crohns Colitis ISSN： 1873-9946 Impact factor: 9.071